IGF-1、IGF-1R在大肠癌中的表达及意义

EXPRESSION AND SIGNIFICANCE OF IGF-1 AND IGF-1R IN COLORECTAL CARCINOMAS

目的:探讨胰岛素样生长因子-l(IGF-l)及其受体(IGF-lR)在大肠癌发病机制中的作用及临床意义。方法:应用免疫组化染色法检测50例大肠癌组织、20例大肠腺瘤和20例正常大肠黏膜中IGF-1和IGF-lR蛋白的表达水平。结果:大肠正常黏膜、腺瘤及癌组织IGF-1、IGF-1R的表达水平逐渐升高,组间比较差异具有统计学意义(P<0.01)。大肠癌组织中,IGF-1和IGF-1R的表达呈正相关(r=0.585,P<0.01)。结论:IGF-1R和IGF-1在大肠癌的发生发展中具有重要作用。

Objective：To investigate the expression and clinical significance of insulin-like growth factor-1 （IGF-1） andinsulin-likegrowthfactor-1receptor（IGF-1R）inpathogenesisofcolorectalcarcinomas.Methods：Immunohistochemical method was used to detect the expression of IGF-1 and IGF-1R protein in 50 cases colorectal carcinomas, 20 cases colorectal adenoma and 20 cases normal colorectal mucosa. Results：From normal colorectal mucosa, colorectal adenoma to colorectal carcinomas, the expression of IGF-1 and IGF-1R protein gradually increased （P＆lt;0.01）. In colorectal carcinomas, the expression of IGF-1 and IGF-1R had positive correlations （r=0.585, P＆lt;0.01）.Conclusions：IGF-1 and IGF-1R may play an important roleindevelopmentofcolorectalcarcinomas.