血浆NT-proBNP水平与不稳定型心绞痛近期预后的关系

RELATIONSHIPS BETWEEN PLASMA NT-PROBNP LEVEL AND SHORT-TERM PROGNOSIS OF UNSTABLE ANGINA PECTORIS

目的:探讨血浆N末端-脑钠肽前体(NT-proBNP)水平与不稳定型心绞痛(UAP)患者近期预后的关系。方法:因胸痛住院并经冠状动脉造影检查确诊为UAP的患者52例,分别检测症状发作后18h和症状缓解96h血浆NT-proBNP水平,并计算差值比。对UAP患者随访30天,记录患者主要心血管事件(MACE)的发生情况,并应用受试者工作曲线(ROC)分析差值比对UAP患者发生近期心血管事件的预测价值。结果:发生心血管事件患者的NT-proBNP差值比高于未发生者,差异具有统计学意义(P<0.05)。ROC结果显示,NT-proBNP差值比为0.99时,其预测UAP患者近期发生心血管事件的灵敏度和特异度分别为64.3%和81.8%。结论:NTproBNP差值比可用来预测UAP患者近期心血管事件的发生情况,可作为筛选高危病例的一个指标。

Objective：To explore the relationships between N-terminal pro-brain natriuretic peptide （NT-proBNP） level and short-term prognosis of unstable angina pectoris （UAP）. Methods：52 UAP patients were hospitalized because of chest pain and confirmed by coronary angiography. The plasma NT-proBNP level of 52 patients was respectively detected 18hafter attacksofsymptoms andremissionofsymptoms for96h, and then calculated the D-value ratio.All the patients were followed up for 30 days and recorded the occurrence of main adverse cardiovascular event （MACE）. ROC curve of D-value ratio was used to analyze the predictive value of D-value ratio for MACE.Results：The D-value ratio of patients with MACE was obviously higher than that of the patients no MACE （P＆lt;0.05）.According to the ROC curve, the predictive sensitivity of MACE was 64.3%and specificity was 81.8%when D-value ratio was 0.99. Conclusions：The D-value ratio of NT-proBNPcanbe usedtopredictMACEinUAP,and can be used as a markerforscreening high-risk patients.