线虫模型与干预帕金森病靶点及药物发现的研究进展

Using Caenorhabditis elegans models of Parkinson' s disease to identify targets and discover the novel drugs

目的对秀丽隐杆线虫在帕金森病药物发现中的作用进行总结,以期对帕金森病的药物发现提供参考。方法通过系统文献调研,以近年来的30余篇外文文献为依据进行归纳总结。结果线虫分子途径的保守性及应用线虫模型进行药物筛选实验的可行性使线虫成为非常有潜力用于发现治疗帕金森病药物的模式生物。结论线虫这一模式生物的引入对于帕金森病药物靶点的发现与确证及新的治疗药物的研究具有重要作用。

Objective To review the studies on Caenorhabditis elegans in Parkinson＇s disease （PD） drug dis- covery. Methods Based on the information from literatures,it can be deduced the utility that the C. elegans model system may have for PD drug discovery. Results The strong conservation of molecular pathways be- tween human and worm, combined with C. elegans utility for high-throughput screening in an intact animal, has made C. elegans a useful tool to identify the molecular targets and pathways of potential drugs. Condusions C. elegans is poised to make significant contributions to the identification and validation of PD drug target and the development of novel therapeutic compounds.