38876例住院患者梅毒监测数据分析

Analysis of the monitoring data of 38876 patients with syphilis

目的调查近1年武汉大学人民医院住院的手术前、输血前、介入前以及辅助生殖技术前患者血清梅毒螺旋体（Treponema pallidum，TP）抗体的检测情况，对梅毒的疾病监测数据进行分析。方法用甲苯胺红不加热血清试验（Toluidine Red Untreated Serum Test，TRUST）和化学发光微粒子免疫检测法（Chemiluminescence microparticle immunoassay，CMIA）分别检测TP非特异性抗体和特异性抗体。结果手术前、输血前、介入前和辅助生殖技术前患者TP特异性抗体阳性率分别为1．54％，1．40％，1．79％和1．44％，TP非特异性抗体阳性率分别为0．28％，0．23％，0．11％，0．41％。统计学分析发现，男、女组TP特异性抗体和非特异性抗体阳性率差异均无统计学意义（P〉0．05）；而不同年龄组间TP特异性抗体阳性率差异有统计学意义（P〈0．05），其中男性组〉60岁患者TP抗体阳性率最高，女性组年龄41-50岁患者TP抗体阳性率最高。结论手术前、输血前、介入前及辅助生殖技术前患者的TP检出率均较高，且与年龄有关。有必要对手术前、输血前、介入前及辅助生殖技术前患者进行TP检测。

Objective To investigate treponema pallidum（TP） infection state in inpatients before operation, transfusion, interventional therapy and assisted reproductive technology in Renmin Hospital of Wuhan University in the past year, and analyze the monitoring data of syphihs. Methods Detecting TP specific antibody by the Syphilis Toluidine Red Untreated Serum Test （TRUST） and TP nonspecific antibody by Chemiluminescence Microparticle Immunoassay （CMIA）. Results The positive rates of TP specific antibody in patients before operation, transfusion,interventional therapy and assisted reproductive technology were 1.54%, 1.40%, 1.79% and 1.44% respectively, and the positive rates of TP nonspecific antibody were 0.28%, 0. 23%, 0. 11%, 0.41%. Statistical analysis showed no obvious difference of positive rates of TP specific antibody and nonspecific antibody between male and female groups. While there were significant differences between different age groups. Further subgroup analysis showed that male patients over 60 years old, and female patients of 41-50 years old had the highest positive rates of TP specific antibody among the inpatients. Conclusions The detection rates of TP antibody were significantly higher in four groups, and should not be ignored. Besides, the detection rates of TP antibody were related with the age of the patients, thus, the detection of TP antibody for these inpatients was necessary.