伴微乳头状分化的胃肠道腺癌的临床病理学特征分析

Clinical pathological characteristics of gastrointestinal adenocarcinoma with micro-papillary differentiation

目的探讨伴微乳头状分化的胃肠道腺癌的临床病理学特征。方法选择2009年1月至2012年12月收治的伴微乳头状分化的胃肠道腺癌50例作为观察组,同期选择普通胃肠道原发腺癌50例作为对照组,观察两组患者的临床病理特征,同时进行EMA、E-Cadherin和IMP3的免疫组织化学分析。结果观察组患者的肿瘤浸润程度和临床分期均显著高于对照组,差异有统计学意义(P<0.05)。观察组患者的EMA表达阳性率为56.0%,对照组患者的EMA表达阳性率为24.0%,差异有统计学意义(P<0.05)。观察组患者的IMP3表达水平高于对照组,而E-cadherin表达水平则明显下降,差异有统计学意义(P<0.05)。结论伴微乳头状分化的胃肠道腺癌具有高侵袭性与高分期的临床特征,可造成EMA和IMP3表达率增加以及E-cadherin表达率降低,提示其有特殊的增殖活性和细胞黏附性。

Objective To investigate the clinical pathological characteristics of gastrointestinal ade- nocarcinoma with micro-papillary differentiation. Methods Selected 50 cases of gastrointestinal adenoear- einoma with micro-papillary differentiation from June 2010 to December 2012 in our hospital as the observa- tion group, and selected 50 cases of primary ordinary gastrointestinal adenocarcinoma at the same period as the control group, The clinical pathological characteristics were observed, The EMA, E-Cadherin and IMP3 were given immunohistochemical analyzed simultaneously. Results The infiltration degree and clinical staging of the observation group were significantly higher, the difference was statistically significant （ P 〈 0. 05）. The EMA expression rate of the observation group was 56. 0%, so that was 24. 0% in the control group that had significantly different compared（ P 〈 0. 05 ）. and the IMP3 expression rate of the observation group was higher while the E. cadherin expression rate were significantly decreased （ P 〈 0. 05 ）. Conclu- sions Gastrointestinal adenocarcinoma with micro-papillary differentiation had high invasiveness and high- stage clinical characteristics that can increase expression of EMA and 1MP3 and decrease the expression of E. cadherin, it indicates that it had special cell proliferation activity and cell adhesion activity.