体位变换和药物保留时间对膀胱癌术后患者的疗效对比分析

Curative effect contrast analysis of position transformation and drug retention time in the postoperative patients with bladder cancer

目的探讨体位变换和药物保留时间对膀胱癌术后患者的影响。方法选取收治的458例行膀胱癌部分切除术的患者,随机分为研究组和对照组,各229例。术后两周灌注吡喃阿霉素,两组体位变换以及药物保留时间不同,观察两组复发以及并发症发生情况。结果两组术后2年复发率对比差异具有统计学意义(P<0.05),研究组血尿、尿频尿痛、前列腺炎、尿道狭窄以及膀胱刺激症状发生率明显低于对照组,两组对比差异均具有统计学意义(P<0.05)。结论膀胱癌术后膀胱内灌注化疗药物及时变换体位,可使药物得到充分吸收。选择合理的保留药物时间,减少了膀胱和尿道的刺激,预防肿瘤复发,降低不良反应发生率。

Objective To explore the effects of position transformation and drug retention time in the postoperative patients with bladder cancer. Methods 458 patients receiving resection of bladder cancer were selected and randomly divided into research group and control group （229 cases respectively ）. After two weeks THP was irrigated. The two groups admitted to different position transformation frequency and drug retention time,and recurrence and complications were observed. Results The difference of postoperative re- currence after years between two groups was statistically significant （ P 〈 0. 05 ）, Hematm＇ia, pollakiuria, uro- dynia,prostatitis,urinary tract stenosis as well as the incidence of bladder irritation symptoms of research group were significantly lower than those of the control group, and the differences were statistically significant （ P 〈 0. 05 ）. Conclusions Postoperative bladder irrigation with THP and timely position transformation can make full absorption of the drug. Reasonable drug retention time can reduce the stimulus of the bladder and urethra, prevent tumor recurrence, and reduce the incidence of adverse reactions.