1Shweiki D, Itin A, Softer D, et al. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angio- genesis[ Jl. Nature, 1992,359:843-845.
2Wang GL,Jiang BH, Rue EA, et al. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension[ J]. Proceedings of the National Academy of Sciences of the United States of America, 1995,92:5510-5514.
3Semenza GL. Targeting HIF-1 for cancer therapy [ J ]. Nature Re- views Cancer, 2003, 3:721-732.
4Zhong H, De Marzo AM,Laughner E, et al. Overexpression of hy- poxiainducible factor-I alpha in common human cancers and their metastases [ J ]. Cancer Research, 1999, 59:5830-5835.
5Williams KJ,Telfer BA, Xenaki D, et al. Enhanced response to radiotherapy in tumours deficient in the function of hypoxia-in- ducible faetor-I [ J]. Radiotherapy and Oncology, 2005, 75: 89-98.
6l.i H, Ko HP, Whitlock JP. Induction of phosphoglycerate kinase 1 gene expression by hypoxia. Roles of arnt and hiflalpha [ J ]. Journal of Biological Chemistry, 1996,271:21262-21267.
7Jaakkola P, Mole DR,Tian YM, et al. Targeting of HIF-alpha to the yon Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxyiation[ J ]. Seience, 2001, 292:468-472.
8Berra E, Benizri E, Ginouves A, et al. HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levets of HIF- l alpha in normoxia[ J ]. EMBO Journal, 2003, 22:4082-4090.
9Wang GL, Semenza GL. General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia[ J ]. Proceedings of the National Academy of Sciences of the United States of A- merica, 1993,90:43044308.
10Laughner E,Taghavi P, Chiles K, et al. HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1 a ( HIF-1a) syn- thesis : novel meehanism for HIF-1 -mediated vascular endothelial growth faetor expression [ J]. Mol Cell Biol, 2001, 21 : 3995-4004.