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缺氧诱导因子-1在肿瘤中作用的研究进展 被引量:1

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摘要 缺氧是实体瘤的基本特征。一般情况下,缺氧细胞可能产生应激性损伤如DNA氧化损伤、DNA链断裂以及遗传性畸变,从而抑制细胞增殖并最终引起细胞死亡。在缺氧环境中,细胞内糖酵解、血管生成、侵袭、造血等方面基凶转录诱导的活跃,与肿瘤细胞生物学特性的改变密切相关。早在20世纪90年代,就有研究小组证实,
作者 冯颖露 陶娟
出处 《中国肿瘤临床与康复》 2014年第2期252-254,共3页 Chinese Journal of Clinical Oncology and Rehabilitation
关键词 HIF-1 缺氧 肿瘤 HIF-1 Hypoxic Tumor
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