摘要
糖尿病的患病人数在全世界持续上升,2型糖尿病早期的特点是胰岛素代谢信号降低、胰岛素抵抗。另外,糖尿病会增加相关心血管疾病和慢性肾脏疾病的风险,会导致心肾性代谢综合征。近年来出现的二肽基肽酶4(DPP4)抑制剂为治疗糖尿病提供了新的选择。该文通过分析胰岛素抵抗、免疫功能、心肾性代谢综合征之间的关联,来阐明DPP4抑制剂作为治疗糖尿病的新途径的可能作用机制,其不仅仅能控制血糖,并能改善胰岛素代谢信号和胰岛素抵抗,还能保护心血管,降低血压。
The population of diabetes continues to rise in worldwide.The characteristic of early type 2 diabetes is insulin resistance caused by decreased insulin metabolic signaling.Diabetes is a very important factor for high risk of cardiovascular disease （CVD）and chronic kidney disease （CKD）and might lead to car-dio-renal metabolic syndrome （CRS）.After investigating the relationship among insulin resistance,immune modulation and CRS,it is suggested that the effect of DPP4 inhibition on diabetes may be more beneficial than glycemic control.DPP4 inhibition can improve insulin metabolic system,as well as insulin resistance signal, protect the cardiovascular system,lower blood pressure.
出处
《新医学》
2014年第2期79-82,共4页
Journal of New Medicine
