过敏性紫癜患儿食物不耐受的检测分析

Analysis of food-intolerance test in children with henoch-schonlein purpura

目的探讨过敏性紫癜(HSP)患儿食物不耐受情况。方法采用ELISA,检测比较该地区58例HSP患儿以及23名正常儿童血清中14种食物特异性IgG(sIgG)水平,并分析不同性别、年龄患儿的不耐受阳性率及不耐受食物的分布差异。结果 58例患儿食物sIgG阳性率为84.5%,高于对照组的13.0%,比较差异有统计学意义(P<0.01)。HSP患儿不耐受的食物前4位依次为:鸡蛋/蛋白蛋黄(70.7%)、牛奶(53.4%)、鳕鱼(19.0%)、螃蟹(10.3%);其中1种食物sIgG阳性18例(31.0%),2种或2种以上食物sIgG阳性31例(53.4%)。不同性别、不同年龄[低龄儿童(<7岁)及高龄儿童(≥7岁)]食物sIgG总阳性率比较差异无统计学意义(P>0.05),高龄儿童的螃蟹IgG阳性率较低龄儿童高(P<0.01)。结论 HSP患儿食物不耐受情况较正常儿童明显。该组HSP患儿对鸡蛋/蛋白蛋黄、牛奶、鳕鱼、螃蟹不耐受情况较为明显,可作为地区参考,高龄儿童对螃蟹的不耐受情况较低龄儿童明显。

Objective To study food hypersensitivity of children with Hennch-Sehonlein purpura （HSP）.Methods The enzyme-linked immunosorbent assay （ELISA）was used to detect 1 4 kinds of food allergen-specific IgG （sIgG）levels in 58 children with HSP and 23 healthy children.Results Eighty-four point five percent（49/58）children with HSP showed food allergen-specific IgG positive（84.5%）higher than healthy children（1 3.0%）（P＆lt;0.05）.Egg（70.7%）,milk（53.4%）,codfish（1 9.0%）and crab（1 0.3%） were the main allergens in HSP.Eighteen cases （31 .0%）with HSP were found to have one type of food aller-gen-specific lgG increment,31 cases （53.4%）with two or more types of sIgG increment.The total positive rate of food sIgG showed no difference between sex and age groups （P〈0.05）.There was higher positive rate of crab IgG in the older children（≥7 years old）（P〈0.05）.Conclusions Food hypersensitivity of children with HSP is more obvious than healthy children.The mainly allergens of these children were egg,milk,cod-fish and crab,which could be regarded as region refernce.The older children is more sensitive to crab.