子宫颈糜烂与子宫颈癌发病率的相关性研究

Correlation study of cervical erosion and the incidence of cervical cancer

目的探讨子宫颈糜烂与子宫颈癌发病率的相关性,为早期预防与干预提供参考。方法选择广西壮族自治区桂东人民医院2012年3月至2013年3月660例妇科门诊子宫颈糜烂女性作为研究组,同时选择300名宫颈光滑的健康体检者作为对照组,均进行子宫颈液基细胞检查,观察两组CINⅠ、CINⅡ、CINⅢ及宫颈癌的发生率。结果宫颈液基细胞学检查(TCT)结果显示,研究组阳性96例,阳性率为14.55%;对照组阳性38例,阳性率为12.67%;两组阳性率及各分组(CINⅠ、CINⅡ、CINⅢ及宫颈癌)之间差异无统计学意义(P>0.05)。进一步行阴道镜检查,研究组宫颈癌前病变49例,占阳性总数的51.04%,宫颈癌变3例,占阳性总数的3.13%;对照组宫颈癌前病变20例,占阳性总数的52.63%,宫颈癌变1例,占阳性总数的2.63%;两组比较差异均无统计学意义(P>0.05)。结论子宫颈糜烂与子宫颈癌发病率无明显的相关性。

Objective To explore the correlation between cervical erosion and the incidence of cervical can- cer, and to provide reference for early prevention and intervention. Methods A total of 660 patients with cervical ero- sion from Guidong People＇s Hospital of Guangxi Zhuang Autonomous Region from March 2012 to March 2013 were selected as the study group, and 300 healthy people with cervical smooth at the same time were enrolled as the control group. All patients were checked the cervical liquid based cytology. The incidence of CIN I, CIN II, CIN Ill and cer- vical cancer of the two groups were observed. Results According to results of the thinprep cervical liquid based cy- tology test （TCT）, 96 cases in the study group were positive （with the positive rate of 14.55%） and 38 cases in the con- trol group were positive （with the positive rate of 12.67%）. The positive rates of the two groups and the incidence of CIN I, CIN 1I, fiN III and cervical cancer between each group had no significant differences （P〉0.05）. According to further colposcope examination, 49 patients in the study group were cervical precancerous lesions, accounting for 51.04% of the total positive cases, 3 patients were cervical cancer, accounting for 3.13% of the total positive cases. Twen- ty patients in the control group were cervical precancerous lesions, accounting for 52.63% of the total positive cases, 1 patient was cervical cancer, accounting for 2.63% of the total positive cases. The two groups showed no significant differ- ences （P〉0.05）. Conclusion There is no correlation between cervical erosion and the incidence of cervical cancer.