社区中老年人抑郁状况与血尿酸等生化指标的相关性调查

Study on the relationship between the elderly depression and serum uric acid and other biochemical indexes in the community

目的了解55岁及以上中老年人抑郁状况,及其与各项生化指标间的关系,为进一步有效防治本地区中老年人群抑郁提供参考依据。方法采用典型抽样方法,于2011年9～11月在宁夏银川市和吴忠市选取5个老龄化社区,以社区55岁及以上符合调查标准的居民为调查对象,采用老年抑郁量表(GDS)和自拟一般情况调查问卷,由统一培训的调查员在社区进行一对一问卷调查,同时采集空腹血清,以备检测各项生化指标。结果共有1 044人完成调查,343人GDS评分超过11分,抑郁总发生率为32.86%,其中轻度抑郁为26.45%,中、重度抑郁为6.41%。回、汉两民族的抑郁发生率差异无统计学意义(P>0.05)。检测的16项生化指标中,血尿酸、总胆红素和间接胆红素在抑郁人群与正常人之间差异有统计学意义(P<0.05)。秩相关分析显示血尿酸、谷氨酰转肽酶(GGT)、总胆红素、直接胆红素、间接胆红素和收缩压与抑郁存在相关性。结论社区中老年人心理健康状况不容乐观,抑郁患病率较高。中老年抑郁患者血尿酸、总胆红素和间接胆红素水平明显降低,指标水平与抑郁程度相一致,且血尿酸、GGT、总胆红素、直接胆红素、间接胆红素和收缩压可能与抑郁存在相关性,早期调节血尿酸等相关指标可有助于中老年抑郁的防治。

Objective To understand depression in the elderly （aged 55 and above）, and to investigate its re- lationship with the biochemical indexes, providing reference for further effective prevention and treatment of the elder- ly. Methods With the method of typical sampling, we selected 5 aging community in Yinchuan and Wuzhong. Geri- atric Depression Scale （GDS） and self-made questionnaire were applied for investigation in volunteers aged 55 years or older. Investigators were trained uniformly. At the same time, fasting serum was collected for the detection of bio- chemical indexes. Results A total of 1 044 completed the survey, among which 343 had GDS score more than 11 points. The total incidence of depression was 32.86%, including mild depression （26.45%） and severe depression （6.41%）. The rate of depression was not significantly difference between nationalities （P〉0.05）. Among the 16 items of biochemical indexes tested, blood uric acid, total bilirubin and indirect bilirubin showed significant differences be- tween the depression group and normal people （P〈0.05）. Rank correlation analysis showed that serum uric acid, GGT, total bilirubin, direct bilirubin, indirect bilirubin and systolic blood pressure had correlation with depression （P〈0.05）.Conclusion The mental health condition of the elderly is not optimistic, with relatively high prevalence of depres- sion. In elderly depressed patients, serum uric acid, total bilirubin and indirect bilirubin levels are significantly lower, consistent with the degree of depression. At the same time, blood uric acid, GGT, total bilirubin, direct bilirubin, indi- rect bilirubin and systolic blood pressure may be correlated with depression. The regulation of the biochemical indexes contribute to the prevention and treatment elderly depression.