社区获得性肺炎合并与未合并全身炎症反应综合征患者N-末端脑钠肽前体水平变化及临床意义研究

The Level of N-Terminal Pro-Brain Natriuretic Peptide in Patients with Community-acquired Pneumonia Associated with or without Systemic Inflammatory Response Syndrome

目的探讨社区获得性肺炎(CAP)合并与未合并全身炎症反应综合征(SIRS)患者N-末端脑钠肽前体(NT-proBNP)水平变化及临床意义。方法选择2012年1月—2013年3月我院住院的CAP患者148例,依据是否合并SIRS分为CAP非SIRS组78例和CAP合并SIRS组70例。采用酶联免疫吸附法测定两组患者的血清NT-proBNP水平,并行肺炎严重指数(PSI)评分。结果 CAP合并SIRS组NT-proBNP水平较CAP非SIRS组升高〔188.0(471.8)和62.5(135.3),P=0.009〕。CAP患者NT-proBNP水平与PSI评分呈正相关(r=0.292,P=0.001)。结论 CAP合并SIRS患者NT-proBNP水平升高,依据NT-proBNP水平可区分CAP是否合并SIRS,并可作为CAP患者病情严重程度及预后的判断指标。

Objective To explore the level of N -terminal pro -brain natriuretic peptide （NT -proBNP） in patients with community -acquired pneumonia （CAP） associated with our without systemic inflammatory response syndrome （SIRS） and its clinical significance. Methods One hundred and forty - eight CAP patients treated in our hospital between January 2012 and March 2013 were included in this study. Based on the presence of SIRS, the patients were divided into non - SIRS group （ n = 78 ） and SIRS group （ n = 70）. The serum level of NT - proBNP was determined by ELISA test, and pneumonia severity index （PSI） score were determined. Results The serum level of NT - proBNP in SIRS group was significantly higher than that in non - SIRS group （ 188.0 （471.8） vs. 62. 5 （ 135.3 ）, P = 0.009 3. The level of NT -proBNP was positively correlated with the PSI score （r = 0. 292, P = 0. 001 ）. Conclusion The level of NT - proBNP was high in CAP patients with SIRS. The level of NT - proBNP may be the indicator of SIRS in CAP patients, which could be used to evaluate the severity or prognosis of CAP.