鼻喷激素联合鼻腔冲洗对儿童上气道咳嗽综合征的疗效观察

Effect of Nasal Spray Hormone Combined with Nasal Douche on Upper Airway Cough Syndrome in Children

目的探讨鼻喷激素联合鼻腔冲洗治疗儿童上气道咳嗽综合征(UACS)的疗效。方法选择2010年6月—2013年6月在本科门诊就诊的咳嗽超过2周的239例患儿,且排除胃食管反流、咳嗽变异性哮喘(CVA)等心肺部疾病,行电子纤维鼻咽镜检查、鼻窦冠状位CT扫描、皮肤过敏原点刺试验(SPT)等检查后符合UACS诊断标准,并将其分为治疗组(129例)和对照组(110例)。治疗组联合使用鼻喷激素和鼻腔冲洗治疗,对照组单纯使用鼻喷激素治疗。评估治疗组与对照组的治疗效果,并采用主观症状评分记录鼻喷激素联合鼻腔冲洗治疗前后的喷嚏、流涕、鼻塞、咳嗽等评分。结果治疗组(显效90例,好转24例,无效15例)疗效优于对照组(显效49例,好转38例,无效23例)(P<0.05)。治疗后治疗组鼻痒、咳嗽、鼻塞、喷嚏、流涕、咽痒症状均较治疗前好转(P<0.05)。结论鼻喷激素联合鼻腔冲洗对UACS引起的儿童慢性咳嗽可起到良好的治疗作用,为临床治疗提供了理论依据。

Objective To explore effect of nasal spray hormone combined with nasal douche on upper airway cough syndrome （UACS） in children. Methods A total of 239 children diagnosed as UACS by electronic fiber pharyngorhinoscopy, paranasal sinus coronal CT scanning, skin prick test （SPT）, etc. were divided into groups study （n = 129, given drug treat- ment combined with nasal douche）, control （110, given drug treatment only）. The therapeutic effects of 2 groups were evalua- ted, and subjective nasal syndrome score was used to record the scores of sneezing, running nose, nasal obstruction, cough be- fore and after nasal spray hormone with nasal douche. Results The therapeutic effect was better in study group than in control group （ excellent 90, 49 ; improvement 24, 38 ; invalid 15, 23 ; P 〈 0.05 ）. The symptoms of nasal itching, cough, nasal congestion, sneezing, running nose, itchy throat, etc. improved after treatment in study group （P 〈 0. 05）. Conclusion Na- sal spray hormone combined with nasal douche has good therapeutic effects on UACS - caused chronic cough in children, which provides theoretical basis for clinical treatment.