熊去氧胆酸联合糖皮质激素治疗药物性淤胆型肝炎疗效观察

Effect of Ursodeoxycholic Acid with Glucocorticoid in Treatment of Drug-induced Cholestasis Hepatitis

目的观察熊去氧胆酸(UDCA)联合糖皮质激素治疗药物性淤胆型肝炎的疗效。方法将134例药物性淤胆型肝炎随机分为治疗组和对照组,两组均予以综合保肝、对症治疗,治疗组则加用熊去氧胆酸和糖皮质激素联合治疗。结果两组总有效率比较无显著性差异(P>0.05),但治疗组显效率与对照组比较有显著性差异(P<0.01);治疗组治疗后总胆红素(TBIL)、谷氨酰转肽酶(GGT)、碱性磷酸酶(ALP)、总胆汁酸(TBA)均低于对照组(P<0.05或P<0.01)。结论联合应用熊去氧胆酸、糖皮质激素可快速、安全、有效地治疗药物性淤胆型肝炎。

Objective To observe curative effect of ursodeoxycholic acid （UDCA） joint glucocorticoid treating drug - induced cholesta- sis hepatitis. Method 134 cases of drug - induced cholestasis hepatitis were randomly divided into treatment group and control group, both groups are integrated protect liver treatment,treatment group added ursodeoxycholic acid and glucocorticoid. Result Treatment group and control group total effective rate was no significant difference （ p 〉 0.05 ）, but significant efficiency compared with the control group with sig- nificant difference （ P 〈 0.01 ） ; After treatment, the treatment group was lower than the control group （P 〈 0.05 or P 〈 0.01 ） in total biliru- bin （TBIL） , gamma glutamyl transpeptidase（GGT） ,alkaline phosphatase （ALP） and total bile acid （TBA）. Conclusion Joint application of ursodeoxycholic acid and glucocorticoid in treatment of drug - induced cholestasis hepatitis curative effect is better.