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中药提取物治疗阿尔茨海默病的研究进展 被引量:9

Research Progress of Chinese Herbal Extract in Alzheimer's Disease
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摘要 阿兹海默症是一种以进行性神经退行性病变为特征的疾病。许多中药提取物具有抗氧化,抗乙酰胆碱酯酶,抗β-淀粉样蛋白毒性,抗炎以及神经保护作用等多重功效,能有效改善阿兹海默症导致的学习和认知功能障碍。列举了8种中药提取物,并阐述其发挥治疗阿兹海默症作用的药理机制。 Objective Alzheimer's disease is a progressive neurodegenerative disease. Many kinds of Chinese herbal extracts have mul- tiple effects such as antioxidant, anti - aeetylcholinesterase, anti - β - amyloid toxicity, anti - inflammatory and neuroprotective effects which can ameliorate learning and cognitive dysfunction resulting from Alzheimer's disease. This article lists eight herbal extracts, and demon- strated their therapeutic role in treating Alzheimer's disease.
作者 杨卉
机构地区 南京中医药大学
出处 《湖北中医药大学学报》 2014年第1期113-115,共3页 Journal of Hubei University of Chinese Medicine
关键词 阿兹海默症 中药提取物 治疗作用 Alzheimer's disease, Chinese herbal extract curative effect
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  • 1Weinmann S, Roll S, Schwarzbach C, et al. Effects of Ginkgo biloba in dementia: systematic review and recta- analysis[ J]. BMC Geriatr, 2010, 10:1-14.
  • 2Lu G, Wu Y, Mak YT, et al. Molecular evidence of the neuroprotec- tire effect of Ginkgo biloba ( EGb761 ) using bax/bcl - 2 ratio after brain ischemia in senescence - accelerated mice, strain prone - 8 [ J ]. Brain Res, 2006,1090( 1 ) :23 - 28.
  • 3Lu J, Zheng YL, Wu DM, et al. Ursolic acid ameliorates cognition deficits and attenuates oxidative damage in the brain of senescent mice induced by D - galactose [ J ]. Biochem Pharmacol, 2007,74 ( 7 ) : 1078 - 1090.
  • 4Akhondzadeh S, Nomozian M, Mohammadi M, et al. Salvia officinalis extract in the treatment of patients with mild to moderate Alzheimer' s disease: a double blind, randomized and placebo - controlled trial [J]. J Clin Pharm Ther, 2003,28(1) :53 -59.
  • 5Chung YK, Heo HJ, Kim EK, et al. Inhibitory effect of ursolic acid purified from Origanum majorana L on the aeetylcho- linesterase[ J]. MoI Cells, 2001, 11(2) :137 -143.
  • 6Porat Y, Abramowitz A, Gazit E. Inhibition of amyloid fibril formation by polyphenols: structural similarity and aromatic interactions as a common inhibition mechanism[ J]. Chem Biol Drug Des, 2006, 67 (1) :23 -37.
  • 7谢卉,朱大会.红景天苷对神经系统疾病药理作用的研究进展[J].中国中药杂志,2012,37(17):2505-2509. 被引量:29
  • 8Yu S, Shen YT, Liu J, et al. Involvement of ERK1/2 pathway in neuroprotection by salidroside against hydrogen peroxide -induced ap- optotic cell death [J]. J Mole Neurosci, 2010,40(3) :321 -31.
  • 9Ze QQ, ~an Z, Yuan SZ, et al. Protective effects of a Rhodiola Cren- ulate extract and salidroside on hippocampal neurogenesis against streptozotocin - induced neural injury in the rat[ J]. PLoS One, 2012, 7(1): 29641.
  • 10Jiang LF, Liao HL, Huang HM, et al. Potential prevention and treat- ment of maifanite for Alzheimer' s disease based on behavior test, oxi- dative stress assay, and trace element analysis in hippocampus of A~3 (25 -35) -induced AD rats[J]. Biol Trace Elem Res, 2013,152 (I) :50 -56.

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