有氧运动对糖尿病肾病大鼠降钙素基因相关肽的影响研究被引量：3

Effects of Aerobic Exercise on Calcitonin Gene-related Peptide in DN Rats

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摘要目的:研究有氧运动对糖尿病肾病(DN)大鼠降钙素基因相关肽(CGRP)的影响。方法:链脉佐菌素(STZ)诱导糖尿病大鼠模型,随机分为糖尿病组(D)、糖尿病运动组(D+E)、同时另设正常对照组(N),有氧运动干预10周后,测定空腹血糖(FBG)、尿微量白蛋白(U-mAIb)、血浆和肾脏组织中内皮素(ET)和CGRP含量。结果:糖尿病大鼠U-mAIb增加,ET升高,CGRP下降,运动干预10周后,D+E组DN大鼠U-mAIb较D组显著降低,ET显著下降,CGRP明显升高。结论:有氧运动对糖尿病大鼠肾脏病变有一定的保护作用,其部分机制可能是通过上调CGRP含量而实现的。 Object： To investigate the effect of aerobic exercise on calcitonin gene-related peptide in diabetic nephropathy（DN） rats. Methods： STZ-induced diabetic rats were randomly divided into two groups： DN rats model group（D）,DN rats exercise intervene group（D＋E）,in addition,normal rats for control group（N）. All rats were fed for 10 weeks. The serum FBG, U-mAIb, ET and CGRP were measured. Results： compared with N group, The content of U-mAIb and ET in DN rats were significantly increased. The level of CGRP was markedly decreased; After the Exercise treatment,the serum CGRP, ET and U-mAIb changes of diabetic rats in the D＋E group were improved. Conclusion： Aerobic exercise could meliorate early kidney hy-perdynamic abnormality in DN rats,possess protective effect on kidney of diabetic rat whose mechanism may be associated partly with a UP-regulation of the CGRP level.

作者龚志刚黄小华

机构地区江西师范大学体育学院湖州市南浔区中西医结合医院检验科

出处《四川体育科学》 2014年第1期33-35,共3页 Sichuan Sports Science

基金江西师范大学青年成长基金(3926)

关键词有氧运动糖尿病肾病降钙素基因相关肽大鼠 Aerobic exercise Diabetic nephropathy Calcitonin gene-related peptide Rats

分类号 G804.5 [文化科学—运动人体科学]

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