期刊文献+

奈达伯联合替吉奥治疗晚期食管癌的疗效观察 被引量:4

下载PDF
导出
摘要 目的:观察替吉奥与奈达铂联合治疗晚期食道癌的临床疗效。方法24例晚期食管癌患者应用替吉奥80 mg/(m2?d),分2次,餐后口服, d1~14,奈达铂80 mg/m2,d1,21 d为1个周期,至少使用2个周期后评价疗效。结果平均每例患者治疗4.56个周期,其中完全缓解(CR)0例,部分缓解(PR)13例(54.2%),稳定(SD)6例(25%),进展(PD)5例(9.2%),总有效率为54.2%,临床获益率(CR+PR+SD)(79.2%),主要不良反应为骨髓抑制。结论替吉奥联合奈达铂治疗晚期食管癌疗效较好,不良亦较小,值得临床推广。
出处 《中国医药指南》 2014年第4期122-123,共2页 Guide of China Medicine
  • 相关文献

参考文献7

二级参考文献30

  • 1张晗.治疗胃癌的复方新药S-1的研究进展[J].国外医学(药学分册),2005,32(5):304-307. 被引量:8
  • 2葛乃建,李苏宜.食管癌内科治疗研究新进展[J].东南大学学报(医学版),2007,26(3):237-240. 被引量:10
  • 3CHU QS,HAMMOND LA,SCHWARTZG, etal. Phase Ⅰ and pharmacokinetic study of the oral fluoropyrimidine S-1 on a oncedaily - for - 28 - day schedule in patients with advanced malignancies [J]. Clin Cancer Res, 2004, 10 ( 15 ) : 4913 -4921.
  • 4SCHOFFSKI P. The modulated oral fluoropyrimidine prodrug S- 1 , and its use in gastrointestinal cancer and other solid tumors [ J ]. Anticancer Drugs ,2004,15 ( 2 ) :85 - 106.
  • 5SHIRASAKA T. Development history and concept of an oral anticancer agent S-1( TS-1 ) : its clinical usefulness and future vistas [J]. Jpn J Clin Oncol,2009,39( 1 ) :2 - 15.
  • 6KOICHI H, NOBORU H, KAZUSAKU T,et al. Pharmacokinetics of S-1 [ J ]. Jpn J Cancer Chemother ,2006,33 ( Suppl 1 ) : S27 - S35.
  • 7YASUHIDE Y. Plasma concentrations of 5-fluorouracil and F - β- alanine following oral administration of S-1, a dihydropyrimi- dine dehydrogenase inhibitory fluoropyrimidine,as compared with protracted venous infusion of 5 - fluorouracil [ J ]. Jpn J Cancer Chemother,2006,33( Suppl 1 ) :S37 - S41.
  • 8KOHEI S,YUH S,TOSHIHIRO K,et al. S-1 for gastric cancer-S- 1 monotherapy and its progress [ J ]. Jpn J Cancer Chemother, 2006,33(Suppl 1 ) :S43 -S51.
  • 9WASABURO K, SATOSHI T, KATSUHIKO H,et al. Clinical development of S-1 for advanced gastric cancer [ J]. Jpn J Cancer Chemother,2006,33 ( Suppl 1 ) :S57 - S63.
  • 10KAZUHIRO Y,YOSHIYUKI W,KAZUAKI T,et al. Combinalion chemotherapy of S-1 and docetaxel on advanced and recurrent gaslric cancer[J].Jpn J Cancer Chemother,2006,33 (Suppl 1 ) : S83 - S86.

共引文献22

同被引文献29

引证文献4

二级引证文献9

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部