SWI评价大鼠脑出血模型血肿演变进程的实验研究

The experimental study of intracerebral hemorrhage development in rat model by MR susceptibility weighted imaging

目的:探讨SWI对大鼠脑出血后血肿演变进程的评估。方法:10只SD大鼠脑实质内注入50μL自体股动脉血,分别在造模后1、6、24、72h行SWI和T2WI动态扫描,分析不同时间点血肿的演变特点。结果:血肿在SWI图像上显示较T2WI更加清晰,SWI测得的血肿体积先呈增大趋势,24h时达到峰值,约49.99μL,72h时血肿体积明显缩小,约34.16μL(F=7.02,P<0.01);在T2WI序列所测的血肿体积也呈相同变化趋势(F=3.18,P<0.05)。在1、6和24h,SWI所测得的血肿体积明显大于T2WI(P<0.05)。结论:SWI对血肿的敏感性高,更能真实反映血肿的演变进程。

Objective.. To investigate the intracerebral hemorrhage （ICH） development in rat model by susceptibility weighted imaging （SWI）. Methods： Ten SD rats were injected 50μL autologous arterial blood into the brain parenchyma respectively. SWI and TzWI dynamic scanning was performed at 1 h,6 h,24 h and 72 h time points after rat modeling in 3.0 T MRI. The develop- ment characterization of ICH in different time points was analyzed. Results： The display of hematoma in SWI was clearer than TzWI. The volume of hematoma measured trended to increase in SWI sequence at first and reached peak（49.99μL） at 24 h af- ter operation and then decreased gradually over time （34.16 μL at 72 h）. Between the two group,there was a significant differ- ence （F= 7.02,P〈0.01）. At the same time, the volume of hematoma also showed the same trend in Tz WI sequence（F： 3.18, Pμ0.05）. But at 1 h,6 h and 24 h time points. The hematoma volume was significantly greater in SWI than that in TzWI （P~ 0. 05）. Conclusion.. SWI sequence is a better research tool and can reflect the development process of ICH more truly in the study of evolution rule of hematoma because of high sensitivity.