NF-κB信号转导与肝脏疾病关系的研究进展

Relationship between NF-κB pathway and liver disease

核因子kappa B(NF-κB)是近年来发现的具有多向调节作用的可诱导的转录因子,它参与多种炎症和免疫应答相关分子基因的表达,同时也参与调控细胞的增殖与分化。有研究表明肝脏在缺血再灌注及肝癌时NF-κB参与调节编码多种炎症介质的基因,如:TNF-α、IL-1、ICAM-1、INOS等,同时NF-κB也调节具有双重调节作用的ROS表达水平。因此,本文就NF-κB与肝脏缺血再灌注损伤、肝癌之间的联系和作用以及针对NF-κB相关的药物治疗作一系统概述。

NF-κB is a polyphonic transcription factor. It is important for the expression of a wide variety of genes that are involved inflammatory and immune responses, and the regulation of cellular proliferation and differentiation. Studies have shown that NF-κB pathway participated in the regulation of encoding a variety of genes of inflammatory mediators in liver cancer and liver ischemia-repeffusion, such as： TNF-α, IL-1, ICAM-1 and INOS. Meanwhile, NF-κB also regulates the expression of ROS. Based on these reasons, this review summarizes the role of NF-κB pathway in the pathogenesis of liver disease, mainly including liver cancer and liver ischemia-reperfusion injure to explore the reasonable therapeutic target.