肝硬化并发消化性溃疡与Helicobacter pylori感染的临床相关性研究

Clinical relevance between liver cirrhosis complicated with peptic ulcer and Helicobacter pylori infection

目的探讨Helicobacter phylori(H.pylori)与肝硬化并发消化性溃疡的临床相关性。方法 H.pylori阳性患者1 887例和H.pylori阴性患者685例,采用Logistic回归分析计算其比值比(OR)和95%CI,以此确定H.pylori感染是否是肝硬化并发消化性溃疡的独立因素。结果 100例失代偿期肝硬化合并消化性溃疡患者,H.pylori阳性38例,H.pylori阴性62例。364例代偿期肝硬化并发消化性溃疡患者,H.pylori阳性195例,H.pylori阴性169例。非肝硬化患者消化性溃疡H.pylori阳性1 654例、H.pylori阴性454例。Logistic回归分析显示,失代偿期肝硬化患者(OR=0.25,P<0.001)和代偿期肝硬化患者(OR=0.52,P<0.001)H.pylori感染率较低。结论 H.pylori感染可能不是肝硬化合并消化性溃疡的主要病因。

Objective To explore the clinical relevance between liver cirrhosis complicated with peptic ulcer and Helieobacter pylori （H. pylori） infection. Methods 1 887 H. pylori-positive patients and 685 H. pylori-negative patients were involved in the study, Logistic regression model was used to calculate the odds ratio （0R） and a 95% confidence interval, the aim was .to determine whether H. pylori infection is the independent factors to cirrhosis peptic ulcer. Results This stuffy included 100 decompensated hepatic cirrhosis patients with peptic ulcers, 38 H. pylori-positive patients and 62 H. pylori-negative patients, 195 H. pylori-positive patients and 169 11. pylori-negative patients of 364 compensated liver cirrhosis complicated with peptic ulcer, among the non-hepatic cirrhosis patients with peptic ulcers, 1 654 were H. pylori-positive and 4,54 were H. pylori-negative. On the basis of Logistic regression analysis, decompensated hepatic cirrhosis patients （ OR =0. 25, P 〈0. 001 ） and compensated hepatic cirrhosis patients （OR =0.52, P 〈0.001） had lower H. pylori infection rates. Conclusion H. pylori may be not the predominant factor for hepatic cirrhosis with peptic ulcer patients.