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TLR-9在细菌DNA诱导小鼠心肌炎症反应中的作用 被引量：2

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摘要 目的 探讨Toll样受体9（TLR-9）及其致病性配体（即细菌DNA CpG-ODN）在脓毒症小鼠心肌炎症反应中的作用.方法 使用人工合成的细菌DNA（CpG-ODN）,分别作用于野生型（WT,C57BL/6）及TLR-9缺陷（TLR9-D）的小鼠,测定不同时间点心肌及血浆炎症标志物：肿瘤坏死因子（TNF-α）、白细胞介素IL-1β及IL-6.结果 在野生型小鼠,CpG-ODN导致心脏及全身发生严重炎症反应,表现为心肌及血浆TNF-α、IL-1β,IL-6的水平显著升高;而TLR9-D小鼠未出现这种炎症反应.结论 细菌DNA（CpG-ODN）通过TLR-9的介导,导致心肌炎性反应及细胞因子的生产.
作者 方丽卉 周秀华
机构地区 中国医科大学附属第四医院危重症治疗科
出处 《中国医师杂志》 CAS 2014年第1期100-102,共3页 Journal of Chinese Physician
基金 2011年辽宁省自然科学基金项目（201102256）
关键词 TOLL样受体9 脓毒症 心肌炎 化学诱导 小鼠
分类号 R542.21 [医药卫生—心血管疾病]
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参考文献12

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同被引文献15

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中国医师杂志
2014年 第1期

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