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右美托咪啶在面部除皱术中的应用 被引量:1

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摘要 目的 观察右美托咪啶(dexmedetomidine,DEX)在局麻下面部除皱术中应用的临床效果.方法 80例择期行面部除皱术患者,年龄35~61岁,ASA分级I-II级,按手术次序编号,随机数字表法分为2组,每组40例:右美托咪啶组(D组)及对照组(C组).D组于手术前15 min给予右美托咪啶负荷剂量0.9 μg/kg,随后以0.4 μg/(kg·h)的速率静脉输注至术毕,C组给予等容量0.9%氯化钠溶液.手术开始前及手术中根据OAA/S镇静评分、VAS镇痛评分予静脉分别注射咪达唑仑、芬太尼,比较2组患者静脉药物的用量,呼吸抑制和手术满意度情况.结果 D组与C组分别有29例(72.5%)和40例(100%)需要加用咪达唑仑,用量分别为(1.75±0.55)mg和(3.5±0.85)mg,D组用量少于C组(P<0.01).所有患者均需追加芬太尼,D组与C组用量分别为(0.08±0.03)mg和(0.11±0.04)mg,D组用量少于C组(P<0.01).D组高血压、心动过速、呼吸抑制发生率明显低于C组(P<0.05),D组对手术过程满意度高于C组(P=0.000).结论 右美托咪啶可在面部除皱手术中减少咪达唑仑及芬太尼用量,减少呼吸抑制的发生,提高患者满意度.
出处 《中国医师杂志》 CAS 2014年第1期113-114,共2页 Journal of Chinese Physician
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参考文献7

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