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硫酸软骨素蛋白聚糖SRPX2在胃肠道肿瘤中的作用 被引量：2

Role of Chondroitin Sulfate Proteoglycan SRPX2 in Gastrointestinal Tumors
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摘要 含sushi重复蛋白X连锁2(SRPX2)是一种具有细胞外基质蛋白性的硫酸软骨素蛋白聚糖。研究显示SRPX2可影响细胞的迁移、黏附等生物学行为,并具有促血管成作用。SRPX2在胃癌和结肠癌组织中呈过表达,并与预后不良相关。本文就SRPX2在胃肠道肿瘤中作用的研究现状作一综述。 SRPX2 （sushi repeat-containing protein,X-linked 2） is a chondroitin sulfate proteoglycan with the feature of extracellular matrix proteins.It has been revealed that SRPX2 can promote cell migration,adhesion and mediate angiogenesis.SRPX2 is overexpressed in gastric cancer and colon cancer tissues and correlated with an unfavorable prognosis.In this review article,the research status of SRPX2 in gastrointestinal tumors was briefly summarized.
作者 刘揆亮 余瑞金 吴静
机构地区 首都医科大学附属北京世纪坛医院消化内科
出处 《胃肠病学》 2014年第2期124-126,共3页 Chinese Journal of Gastroenterology
基金 北京市自然科学基金资助项目(7133239)
关键词 含sushi重复蛋白X连锁2 蛋白聚糖类 细胞外基质 胃肠肿瘤 Sushi Repeat-Containing Protein, X-Linked 2 Proteoglycans Extracellular Matrix Gastrointestinal Neoplasms
分类号 R735 [医药卫生—肿瘤]
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参考文献18

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同被引文献17

  • 1Tanaka K,Arao T,Tamura D,Aomatsu K,Furuta K,Matsumoto K,Kaneda H,Kudo K,Fujita Y,Kimura H,Yanagihara K,Yamada Y,Okamoto I,Nakagawa K,Nishio K.SRPX2 is a novel chondroitin sulfate proteoglycan that is overexpressed in gastrointestinal cancer.PLoS One 2012;7:e27922.
  • 2Kurosawa H,Goi K,Inukai T,Inaba T,Chang KS,Shinjyo T,Rakestraw KM,Naeve CW,Look AT.Two candidate downstream target genes for E2A-HLF.Blood 1999;93:321-332.
  • 3Wilson R,Norris EL,Brachvogel B,Angelucci C,Zivkovic S,Gordon L,Bernardo BC,Stermann J,Sekiguchi K,Gorman JJ,Bateman JF.Changes in the chondrocyte and extracellular matrix proteome during post-natal mouse cartilage development.Mol Cell Proteomics 2012;11:M111.014159.
  • 4O'Leary JM,Bromek K,Black GM,Uhrinova S,Schmitz C,Wang X,Krych M,Atkinson JP,Uhrin D,Barlow PN.Backbone dynamics of complement control protein (CCP) modules reveals mobility in binding surfaces.Protein Sci 2004;13:1238-1250.
  • 5Tanaka K,Arao T,Maegawa M,Matsumoto K,Kaneda H,Kudo K,Fujita Y,Yokote H,Yanagihara K,Yamada Y,Okamoto I,Nakagawa K,Nishio K.SRPX2 is overexpressed in gastric cancer and promotes cellular migration and adhesion.Int J Cancer 2009;124:1072-1080.
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  • 7Royer B,Soares DC,Barlow PN,Bontrop RE,Roll P,Robaglia-Schlupp A,Blancher A,Levasseur A,Cau P,Pontarotti P,Szepetowski P.Molecular evolution of the human SRPX2 gene that causes brain disorders of the Rolandic and Sylvian speech areas.BMC Genet 2007;8:72.
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  • 9Salmi M,Bruneau N,Cillario J,Lozovaya N,Massacrier A,Buhler E,Cloarec R,Tsintsadze T,Watrin F,Tsintsadze V,Zimmer C,Villard C,Lafitte D,Cardoso C,Bao L,Lesca G,Rudolf G,Muscatelli F,Pauly V,Khalilov I,Durbec P,Ben-Ari Y,Burnashev N,Represa A,Szepetowski P.Tubacin prevents neuronal migration defects and epileptic activity caused by rat Srpx2 silencing in utero.Brain 2013;136:2457-2473.
  • 10Yamada T,Oshima T,Yoshihara K,Sato T,Nozaki A,Shiozawa M,Ota M,Yoshikawa T,Akaike M,Numata K,Rino Y,Kunisaki C,Tanaka K,Imada T,Masuda M.Impact of overexpression of Sushi repeat-containing protein X-linked 2 gene on outcomes of gastric cancer.J Surg Oncol 2014;109:836-840.

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胃肠病学
2014年 第2期

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