肠道微生物与变应性疾病

Intestinal microorganisms and allergic diseases

变应性疾病的发病机制至今尚不清楚,近年的一些研究表明肠道微生物可能在该病的发病中扮演着重要角色,本文将着重讨论肠道微生物如何调节机体免疫及对变应性疾病发病的影响。1概述目前变应性疾病的患病率在全球范围内日益增多,每年有成千上万的患者向医疗提供者寻求帮助。该病不仅严重影响患者的生活质量,还会加重社会及个人的经济负担,因此预防和控制该病已成为一个世界性的卫生问题。

Summary According to the ＂hygiene hypothesis＇, the intestinal microbes would not only regulate local immune status, but also affect systematic immune homeostasis, which may play an important role in the pathogenesis of al- lergic diseases. This review will mainly focus on investigating the intricate relationships among intestinal microbes, immune system and allergic diseases. Multiple factors affecting gut microorganisms may influence the immune ho- meostasis directly and later become risk factors of allergic diseases. This point of view may pave the way for the de- sign of new interventions to the diseases.