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失交感神经支配对拔牙窝骨愈合期间血管再生的影响 被引量：1

Effect of Sympathetic Denervation on Angiogenesis during the Period of Extraction Socket Healing
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摘要 目的通过建立失交感神经支配模型,研究失交感神经支配对拔牙窝骨愈合期间血管再生的影响作用。方法利用颈上神经节切除术建立SD大鼠单侧失交感神经支配大鼠模型,并通过免疫组织化学染色技术检测术后1,3,7,14和21d5个时间点拔牙窝的血管内皮细胞数量及ETS相关基因(ERG)表达。结果实验组第3,7,21d时血管内皮细胞数量明显多于对照组(P<0.05),余时间点差别无统计学意义(P>0.05)。实验组第7,21d时血管内皮细胞表达ERG积分光密度(IOD)值明显高于对照组(P<0.05),余时间点差别无统计学意义(P>0.05)。结论失交感神经支配可以促进血管再生和血管内皮细胞ERG表达。 Objective To investigate the effect of sympathetic denervation on angiogenesis during extraction socket healing period by establishing sympathetic denervation model . Methods Sympathetic denervation model was established by modified unilateral superior cervical ganglionectomy （SCGx） in Spra-gue-Dawley rats . We used immunohistochemistry to detect the number of vascular endothelial cells and ERG expression at 1 ,3 ,7 ,14 and 21 days after surgery in extraction socket . Results Compared with the control group ,the number of endothelial cells （at 3 ,7 and 21 days） and IOD values of ERG （at 7 and 21 days） were significantly higher in the SCGx group （all P＆lt;0 .05） . Conclusion Sympathetic denerva-tion promotes angiogenesis and ERG expression in vascular endothelial cells .
作者 陈伟辉 林海 王承勇 王锦 卢萌 危红英 张德庆
机构地区 福建医科大学附属协和医院口腔颌面外科 福建医科大学牙颌面畸形防治研究室 厦门市口腔医院种植科 浦城县医院口腔科 龙岩市第二医院口腔科
出处 《福建医科大学学报》 2013年第6期335-339,共5页 Journal of Fujian Medical University
基金 国家自然科学基金(31070838) 福建省杰出青年科学基金(2012J06017) 福建省卫生厅青年科研课题(2011-2-8)
关键词 交感神经系统 拔牙 内皮 血管 伤口愈合 骨生成 骨再生 sympathetic nervous system tooth extraction endothelium,vascular wound heal-ing osteogenesis bone regeneration
分类号 R782.11 [医药卫生—口腔医学]
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参考文献18

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共引文献2

同被引文献23

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福建医科大学学报
2013年 第6期

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