米索前列醇预防产后出血的效果观察

Prevention of Postpartum Bleeding by Misoprostol

:为了预防产妇产后出血 ,将 2 90例单胎、头位、无妊娠合并症、无前列腺素禁忌证、经阴道分娩的产妇随机分为 3组 : 组 98例 ,胎儿前肩娩出后口服米索前列醇 6 0 0 μg; 组 93例 ,胎儿娩出后静脉注射缩宫素 2 0 U; 组 99例 ,上述两种药物相继应用。观察不同时段出血量、产后出血发生率及生命体征变化。结果产后 2 4h出血量及出血发生率分别为 : 组 (4 43.71± 12 9.0 0 ) ml,2 0 .41% ; 组 (5 6 6 .0 0± 134.0 1) ml,40 .86 % ; 组 (4 5 3.35±16 3.5 4) ml,32 .32 %。 组与 组比较 ,差异有显著性 (均 P<0 .0 5 ) ; 组与 组比较 ,差异无显著性 (均 P>0 .0 5 ) ; 组与 组比较 ,前者差异有显著性 (P<0 .0 5 ) ,后者差异无显著性 (P>0 .0 5 )。提示单独应用米索前列醇可有效预防产后出血 ,降低产后出血发生率 。

In order to prevent the postpartum bleeding, 290 normal parturients were randomly divided into three groups: group Ⅰ, 98 cases, receiving misoprostol 600 μg po. after delivery; group Ⅱ, 93 cases, receiving oxytocin 20 U i.v after delivery; group Ⅲ, 99 cases, receiving the two drugs. The amount of postpartum bleeding at different intervals, the recurrence of postpartum bleeding and the changes in vital signs were observed. The results showed that the mean amount of postpartum bleeding and the recurrence of postpartum bleeding 24 h after delivery were (443 71±129 00)ml and 20 41%,(566 00±134 01)ml and 40 86%, and(453 35±163 54)ml and 32 32% in the three groups respectively. There was significant difference between group Ⅰ and Ⅱ ( P <0 05) and no significant difference between group Ⅰ and Ⅲ ( P >0 05). There was significant difference of the former and no significant difference of the latter between group Ⅱ and Ⅲ. It was suggested that misoprostol could efficiently reduce the amount of postpartum bleeding and the recurrence of postpartum bleeding.\;