P物质对大鼠PO/AH温度—性敏感神经元放电活动的影响

Effect of SP on Electroactivities of Thermo Estradiol Related Sensitive Neurons in PO/AH of Rats

目的 :探讨 P物质对视前区下丘脑前部 (PO/ AH)温度 -性激素敏感相关神经元电活动的影响。方法 :采用微电极细胞外引导单位放电的电生理手段 ,记录 P物质对大鼠 PO/ AH温度 -雌激素敏感相关神经元放电活动的影响。结果 :在 PO/ AH共记录到 9例热 -雌激素敏感相关神经元 ,4例冷 -雌激素敏感相关神经元 ;雌激素兴奋热敏神经元 ,而抑制冷敏神经元的电活动 ;尾静脉注射 P物质分别反转了雌激素对这两类神经元放电活动的影响。结论 :P物质对体温调节活动影响的途径之一是改变 PO/ AH的温度

Objective: The aim of this study was designed to certify the effects of substance P(SP) on thermo gonohormonal neuron. Methods: We used the technique of extracellular microelectrode recording, and examined the effects of intravenously injections of SP on electroactiveties of thermo gonohormonal neurons in PO/AH of rats. Results: Total of 9 warm estradiol sensitive and 4 cold estradiol sensitive neurons were recorded in PO/AH, where estradiol excited electroactivities of the warm estradiol sensitive neurons but inhibited those of the cold estradiol sensitive ones. While SP reversed the effects of estradiol bezonate on the above mentioned neurons. Conclusion: From our results and related data we may draw conclusions that the thermoregulatory effects of SP may be functioned via hermo gonohormonal neuron.