肺肿瘤倍增时间及其与原发性肺癌病人预后关系的探讨

The Relationship Between Doubling Time of Lung Neoplasms and the Prognosis of Patients with Primary Lung Cancer

目的 :研究肿瘤倍增时间 (doubling tim e,TD)与原发性肺癌病人预后的关系。方法 :根据肿瘤或阴影的直径 ,计算 TD,然后按 Geddes'nom ogram图表预测病人的生存时间 (PST) ,并与病人的实际生存时间 (AST)比较 ,结果进行统计学分析。结果 :TD 值在不同病理类型病变中无差异 (P >0 .0 5 )。TD>10 0 d的病人累计生存率比 TD≤ 10 0 d的病人高 ,两者差异显著 (P <0 .0 5 )。经手术治疗后的病人生存时间 (平均 36 .1月 )明显高于预测的生存时间 (平均 2 5 .6 5月 ) ,说明手术治疗有效。结论 :TD

Objective: Our aim was to investigate the relationship between tumor doubling time (T D) and the prognosis of patients with lung cancer.Methods:According to the diameter of tumor or its shadow,the T D of tumor was calculated and postoperative survival time (PST) were predicted based on the Geddes' nomogram The statistic analysis was performed after comparison with the actual survival time (AST).Results:There was no significant difference of T D among tumors of different histological types (P>0.05).The accumulated survival in patients with T D>100 days was higher than those with T D<100 days, with a significant difference (P<0.05).The AST in patients underwent surgery was markedly higher than the PST,indicating that the operation was effective.Conclusion:Tumor T D may be a valuable parameter for evaluating the prognosis and surgical treatment in patients with lung cancer.