诱导型一氧化氮合酶在心肌梗死进程中的研究进展

Advances of inducible nitric oxide synthase in the process of myocardial infarction

一氧化氮(NO)是在一氧化氮合酶(NOS)催化下生成,其在心血管疾病中发挥了重要作用。诱导型一氧化氮合酶(iNOS)在心脏缺血应激情况下表达,并产生大量一氧化氮而作用于免疫系统和心血管系统。心肌梗死(MI)后,免疫系统的巨噬细胞及心血管系统的成纤维细胞、血管内皮细胞参与心肌瘢痕的形成。本文就国内外关于诱导型一氧化氮合酶与上述三类细胞的研究进展做一述评,以明确诱导型一氧化氮合酶在心肌梗死进程中的作用。

Nitric oxide plays an important role in cardiovascular disease, and nitric oxide is in the production of ni- tric oxide synthase catalyzed. Inducible nitric oxide synthase expresses in the ischemie cardiac stress situations which pro- duce large amounts of nitric oxide to play a role on the immune system and cardiovascular system. After myocardial in- farction, immune system of macrophage and cardiovascular system of fibroblasts, endothelial cells which are involved in the formation of myocardial scar. Hereby abroad on about inducible nitric oxide synthase and the three types of cell re- search were reviewed, in order to further clarify the inducible nitric oxide synthase in the role in the process of myocardial infarction.