摘要
目的探讨阿司匹林时间治疗对降压作用的影响及其机制。方法以2012年1月～2013年1月收治的80例中重度高血压患为研究对象，随机分为晨服组和夜服组各40例，所有患者均进行生活行为干预及基础药物治疗，晨服组患者清晨服用阿司匹林，夜服组患者夜晚服用阿司匹林．比较两组患者血压控制情况、心血管事件独立预测因子、血小板参数和血小板膜蛋白水平之间的差异。结果夜服组患者血压控制情况和血小板参数皆较晨服组更理想，心血管事件独立预测因子C反应蛋白与高血清同型半胱氨酸（Hcy）低于晨服组，夜服组患者血小板膜蛋白含量低于晨服组，差异均有统计学意（均P〈0．05）。结论夜服阿司匹林能够更有效地控制中重度高血压患者的血压状况，且对预防患者发生心血管事件有积极作用，其机制可能与抑制血小板活化及功能作用有关。
Objective To analyze the time effect of aspirin in the treatment for lowering blood pressure in the pa- tients with hypertension. Methods 80 patients with hypertension were divided into morning medicine group and night medicine group. The patients in morning medicine group were used aspirin every morning and the patients in night medi- cine group were used aspirin every night. The difference of the effect of blood pressure control, the level of C-reactive protein, homocysteine （Hcy）, platelet parameters and platelet membrane protein degree between the two groups were compared. Results The effect of blood pressure control in the night group was better than that in the control group. The level of C-reactive protein, homocysteine （Hcy）, platelet parameters and platelet membrane protein degree of the patients in the night group were lower than that in the control group. Conclusion It would get a satisfactory effect to use aspirin every night in the treatment for lowering blood pressure in the patients with hypertension, with the better effect of blood pressure control. In the study, the mechanism could be interpreted as the activity of platelet.
出处
《西部医学》
2014年第3期310-313,共4页
Medical Journal of West China
基金
佛山市卫生局科研课题(2013402)
