支扩方对支气管扩张症模型气道组织过氧化作用的影响

Peroxidization Effect of TCM Medicine on Airway Model of Bronchiectasis

目的 :探讨中药支扩方对支气管扩张症模型气道组织 SOD、MDA的影响 ,揭示中药对气道组织过氧化作用的机理。方法 :建立直接叶支气管内注射绿脓杆菌的大鼠支气管扩张症模型 ,观察中药与氧氟沙星对支扩模型周围血炎细胞密度、肺组织匀浆 SOD、MDA的影响。结果 :中药对炎细胞密度、肺组织匀浆 SOD、MDA的作用优于氧氟沙星 (P<0 .0 5 )。结论 :中药可能是通过降低炎细胞密度 ,抑制气道粘膜细胞脂质过氧化 ,促进支气管及其周围肺组织修复而达到治疗目的。

Objective:To explore the TCM medicine(Zhikuofang,支扩方) on the SOD and MDA of the airway model of bronchiectasis and the peroxidization.Method:The airway model of bronchiectasis(AMB) was set up and infused with Bacillus pyocyaneus.Result:SOD and MDA of the lung tissue and the density of the inflammation syndrom differentiation cells around the AMB were compared between the TCM medicine and the Ofloxacin(P<0 05).Conclusion:The TCM medicine probably treat bronchiectasis with decreasing the inflammation cells and restrain the peroxidization and promoting the repairation of lung tissue.