慢性阻塞性肺疾病患者血清肺表面活性蛋白D水平变化及其临床意义

Serum levels of surfactant protant protan Din COPD: changes and clanges and clinieal sighificance

目的探讨慢性阻塞性肺疾病患者血清肺表面活性蛋白D水平变化及其临床意义。方法选取COPD急性加重期患者30例、COPD稳定期患者30例及对照者30例,分别测定其血清SP-D水平,并与COPD患者严重程度进行相关分析。结果 COPD急性加重、稳定期患者血清SP-D水平均高于对照组(P<0.05);COPD急性加重组患者血清SP-D水平明显高于稳定期组(P<0.05)。相关性分析结果显示:COPD急性加重、稳定期患者血清SP-D水平与一秒钟用力呼气容积占预计值百分比(FEVl%pred)均呈负相关(P<0.05)。结论 COPD急性加重、稳定期患者血清SP-D水平均高于对照组,血清SP-D水平变化可作为判定COPD病情严重程度的指标之一。

Objective To explore the changes and clinical significance of serum levels of surfactant protein D （ SP - D） in the patients with chronic obstructive pulmonary disease（COPD）. Methods 30 cases of acute exacerbation of COPD （ acute exacerbation of COPD group）, 30 cases of stable COPD （ stable COPD group） and 30 cases healthy subjects （ healthy control group） were measured for serum levels of SP - D, which were then analyzed for their correlation with COPD severity. Results Serum levels of SP- D in the two COPD groups were higher than those in control group（P 〈0. 05）. Serum levels of SP - D in acute exacerbation of COPD were significantly higher than those in stable COPD（P 〈0. 05）. The correlation analysis results showed that serum levels of SP - D in the two COPD groups were negative correlated with FEV1% pred（P 〈 0.05 ）. Conclusions The serum levels of SP - D in the two COPD groups are higher than those in control group, therefore, serum level of SP - D can be used as an indicator in judging the severity of COPD.