康艾注射液联合化疗治疗老年晚期非小细胞肺癌疗效观察

目的观察康艾注射液联合TP方案（紫杉醇＋顺铂）方案治疗老年晚期非小细胞肺癌临床效果。方法将南阳医学高等专科学校第一附属医院收冶的56例老年晚期肺癌患者随机分为观察组和对照组，两组各38例。两组均采用TP方案化疗，21d为1个周期，共治疗2个周期，观察组白化疗开始时即联用复方康艾针，康艾注射液50ml入5％葡萄糖注射液，静滴1次/d，每周期Hd，观察化疗2个周期后化疗近期疗效、患者化疗不良反应发生情况、骨髓抑制情况。结果观察组近期疗效（CR＋RR）为5383％，对照组为3570％，差异无统计学意义，但观察组生活质量改善情况明显高于对照组，差异有统计学意义（P〈0.05）；对照组骨髓抑制情况、白细胞下降程度、贫血程度均较对观察组明显，差异有统计学意义（P〈0.05）；两组患者化疗后血小板改变情况差异无统计学意义；观察组化疗过程中消化道毒性总发生率为1786％，且多为Ⅰ～Ⅱ度，对照组消化道不良反应发生率为42.86％，两组比较差异有统计学意义（P〈0.05），化疗后体重增加情况观察组较对照组明显，差异统计学意义（JD〈0.05）。结论康艾注射液联合化疗、减轻化疗痛苦、改善患者生活质量。

Objective To observe the effect of Kangai injection combined with TP regimen（paclitaxel＋cisplatin） in the treatment of elderly patients with advanced non-small cell lung cancer, Methods 56 cases of metastatic lung cancer patients were divided into two groups,28 cases of the control group,Two groups were used tp chemotherapy, 21 days was a period ,the treatment continued for 2 cycles, the observation group started chemotherapy Aikang needle injection 50 mLKang ai into 5% dextrose injection, intravenous infusion of I day, 14 days was a cycle, chemotherapy term efficacy after two cycles of chemotherapy, the incidence of adverse reactions in patients with chemotherapy, bone marrow suppression situation were observed. Results Term effect of observation group （CR ＋ RR） was 53.83,in the control group term efficacy （CR ＋ RR） was 35.70%, the difference was not statistically significant, but the observation group was significantly higher quality of life to improve the situation, the difference was statistically significance （P〈0.05）; bone marrow suppression control group situation, leukopenia extent, the degree of anemia than those on the observation group was significantly, with statistical significance （P〈0.05）; groups of patients after chemotherapy, no significant difference in platelet changing circumstances;total incidence of gastrointestinal toxicity in observation group during chemotherapy was 17.86%, and all was Ⅰ-Ⅱ degree,gastrointestinal adverse reactinos in the control group was 42.86%,there was a statistically significant difference between the two groups （P〈0.05）, body mass after chemotherapy increased in observation group than in the control group, with statistical significance （P〈0.05）.Conclusion Kang＇ai injection combined with chemotherapy can enhance the efficacy of chemotherapy, reduce chemotherapy pain and improve patient quality of life.