巨噬细胞凋亡对结核分枝杆菌感染的机制研究进展

Progress of Research on the Mechanism of Apoptosis of Macrophages Infected with Mycobacterium Tuberculosis

结核病是一种严重危害人类健康的慢性传染性疾病,主要由结核分枝杆菌感染导致,结核分枝杆菌进入人体后,与免疫防御的第一道屏障—巨噬细胞发生反应,部分菌株在细胞内长期生存、繁殖,是导致结核病转归的决定性因素。感染早期,结核分枝杆菌的繁殖受到巨噬细胞凋亡的抑制,随着高效价、高毒力菌株繁殖速度的增加,抗巨噬细胞凋亡作用不断增强,使自身繁殖得到有效保护,为菌株的生长提供了充足、适宜的胞内环境。因此,调控结核分枝杆菌对巨噬细胞凋亡进程的抑制作用,是预防和治疗结核病的关键。

Tuberculosis is a chronic infectious disease serious harm to human health, is mainly composed of Mycobacterium tuberculosis infection. When Mycobacterium tuberculosis entered into the human body and led immune macrophage reaction, some strains were long-term survival and made reproduction, which is the decisive factor leading to tuberculosis. In the early stage of infection, Mycobacterium tuberculosis growth was inhibited by apoptosis of macrophages. With the increase of high titer, high virulent strains i^reeding rate, the effect of macrophage on apoptosis increases ceaselessly, and make their own reproduction can be effectively protected, providing sufficient, appropriate intracellular environment for the growth of strains. Therefore, the inhibition of Mycobacterium tuberculosis to the regulation of macrophage apoptosis process is the key to the prevention and treatment of tuberculosis.