微创保胆术后胆囊功能恢复的影响因素分析

Analysis for factors affecting gallbladder function recovery after minimally invasive gallbladder-preserving surgery

目的:探讨微创保胆术后胆囊功能恢复的影响因素。方法:采用完全随机化病例对照设计,从保胆取石术后随访满1年的患者里随机抽取59例,其中胆囊功能恢复良好37例,功能恢复差22例,对术后胆囊功能恢复的影响因素行统计分析。结果:单因素分析显示,年龄、胆囊壁厚度、黏膜下结石、炎性病理、结石复发、糖尿病、手术时间、术后服药与患者胆囊功能恢复有关(均P<0.05);Logistic回归分析表明,影响胆囊功能恢复的危险因素为:结石复发(OR=13.121,P=0.046)、糖尿病(OR=12.263,P=0.043)、炎性病理(OR=6.891,P=0.037)、手术时间(OR=6.718,P=0.030)。结论:结石复发、糖尿病、胆囊长期慢性炎症、长时间手术操作是微创保胆术后胆囊功能恢复差主要影响因素。

Objective： To determine the factors affecting cholecystolithotomy with gallbladder preservation. gallbladder function recovery after minimally invasive Methods： Using completely randomized case-control design, 59 cases were selected among the patients who underwent minimally invasive gallbladder-preserving cholelithotomy after the completion of 1-year follow-up. Of the patients, 37 cases had excellent gallbladder function recovery and 22 cases had poor gallbladder function recovery, The factors affecting the postoperative gallbladder function recovery were statistically analyzed. Results： Univariate analysis showed that age, thickness of the gallbladder wall, submucosal calculi, inflammatory pathology, stone recurrence, diabetes mellitus, operative time and postoperative drug administration were associated with gallbladder function recovery of the patients （all P〈0.05）. Logistic regression analysis revealed that stone recurrence （0R=13.121, P=0.046）, diabetes mellitus （OR=12.263, P=0.043）, inflammatory pathology （OR=6.891, P=0.037） and operative time （OR=6.718, P=0.030） were riskfactors for gallbladder function recoverla Conclusion： Stone recurrence, diabetes mellitus, long-term （chronic） inflammation of the gallbladder and long operative time are the main factors hampering gallbladder function recovery after minimally invasive gallbladder-preserving surgery.