红豆蔻黄酮类化学成分研究

Flavonoids from the seeds of Alpinia galanga Willd

本文对红豆蔻中的黄酮类化学成分进行了研究。通过硅胶、Sephadex LH-20等柱色谱和制备液相等多种色谱方法,从红豆蔻95%乙醇提取物中分离得到10个黄酮类化合物。根据理化性质和波谱数据分别鉴定为(2R,3S)-pinobaksin-3-cinnamate(1)、(2R,3R)-pinobaksin-3-cinnamate(2)、乔松素(pinocembrin,3)、短叶松素(pinobaksin,4)、3-O-乙酰基短叶松素(3-O-acetylpinobaksin,5)、高良姜素(galangin,6)、高良姜素-3-甲醚(galangin-3-methylether,7)、华良姜素(kumatakenin,8)、山柰酚-3-甲醚(3-methylkaempferol,9)和(2R,3R)-3,5-dihydroxy-7-methoxyflavanone(10)。其中化合物1为新化合物,化合物2、5、10为首次从该属植物中分离得到,其余化合物皆为首次从该植物中分离得到。

Ten flavonoids were isolated from the 95% ethanol extract of the seeds of Alpinia galanga Willd. with a combination of various chromatographic techniques, including silica gel, Sephadex LH-20 and preparative HPLC. On the basis of spectroscopic data analysis, they were elucidated as （2 R, 3S）-pinobaksin-3- cinnamate （1）, （2R, 3R）-pinobaksin-3-cinnamate （2）, pinocembrin （3）, pinobaksin （4）, 3-O-acetylpinobaksin （5）, galangin （6）, galangin-3-methylether （7）, kumatakenin （8）, 3-methylkaempferol （9） and （2R, 3R）-3, 5-dihydroxy- 7-methoxyflavanone （10）. Among them, compound 1 is a new compound, compounds 2, 5 and 10 were isolated from the genus Alpinia for the first time, and others were isolated from this plant for the first time.