抗青光眼术后中央角膜厚度变化及其与眼压的相关性研究

Central corneal thickness changes after glaucoma surgery and its correlation with intraocular pressure

目的探讨抗青光眼术后中央角膜厚度（central corneal thickness，CCT）变化及其与眼压（intraocular pressure，IOP）的相关性。方法选取2009年10月至2011年12月于我院就诊的青光眼患者40例（60眼），采用穿透性小梁切除术结合周边虹膜切除术或非穿透性小梁手术，分别于术前及术后1周、1个月、3个月、6个月行常规检查，包括CCT、IOP、裂隙灯检查等。采用Spearman法分析CCT与IOP之间的相关性。结果术后1周CCT（539．8±44．8）μm，与术前（556．6±42．6）μm相比，差异有统计学意义（P〈0．05）；1个月后CCT略有上升，3个月与6个月后CCT变化甚微，术后不同时间点间CCT差异均无统计学意义（均为P〉0．05）。术后1周IOP显著降低，与术前相比，差异有统计学意义（P〈0．05）；术后1个月稍微升高，术后3～6个月变化不大，较为稳定，术后不同时间点间IOP差异均无统计学意义（均为P〉0．05）。术前CCT与IOP无相关性（r=0．110，P=0．910），虽然术后1周CCT与IOP呈一定程度的正相关性（r=0．317，P=0．045），但相关性较低，术后1个月、3个月、6个月CCT与IOP均无相关性（r=0．196、0．101、0．051，P=0．312、0．453、0．702），因此可以认为手术前后IOP与CCT值均无明显相关性。结论抗青光眼术后CCT下降．其与IOP相关性不明显。

Objective To discuss the changes of central corneal thickness（CCT） after glaucoma surgery, and analyze its relationship with intraocular pressure （IOP）. Methods A total of 60 eyes in 40 patients with glaucoma were chosen,all patients re- ceived the trabeculectomy combined with periphery iridectomy or non-penetrating trab- eculectomy, the CCT, IOP at pre-operation and postoperative 1 week, 1 month, 3 months,6 months were checked,the correlation between CCT and IOP were analyzed by Spearman methods. Results CCT at postoperative 1 week was （ 539. 8 ± 44. 8 ） μm,compared with pre-operation （ 556.6 ± 42.6 ） μm, there was statistical difference （P 〈 0.05 ）. CCT at postoperative 1 month slightly increased, stabled at postoperative 3 months and 6 months, there was no statistical difference between postoperative time points（ all P 〉 0. 05 ）. IOP at postoperative 1 week was the lowest, compared with pre- operation,there was statistical difference （P 〈 0. 05 ）. IOP at postoperative 1 month slightly increased, stabled at postoperative 3 months and 6 months, there was no statisti- cal difference between postoperative time points（all P 〉0.05）. There was no correlation between preoperative CCT and IOP（r =0. ll0,P =0. 910） ,they correlated at postoperative 1 week（ r =0. 317 ,P =0. 045 ） ,but the coefficient was very low,there was no statistical difference at postoperative 1 month,3 months and 5 months between CCT and IOP（ r = 0. 195,0. 101,0. 051 ,P =0. 312,0. 453,0. 702）, so it could be considered that there was no correlation between CCT and IOP. Coneluuion CCT decrease after glaucoma surgery and it has no obvious correlation with IOP.