外周型苯二氮类受体在肝细胞癌中表达及其与临床病理特征及预后关系

Expression of PBR and Its Correlation with Clinicopathologic Characteristic and Prognosis in Human Hepatocellular Carcinomas

【目的】探讨外周型苯二氮类受体(PBR)蛋白在肝细胞癌组织中表达情况以及分析其与肝癌患者临床病理特征及预后的关系。【方法】采用免疫组织化学EnVision方法检测109例肝细胞癌组织中PBR蛋白的表达情况,并分析其与临床病理特征和预后的关系。【结果】PBR蛋白在109例肝癌组织中阳性表达有68例(62.4%);相关性分析结果显示,PBR蛋白在肝癌组织中高表达与肿瘤大小、肿瘤分化程度、肿瘤包膜、卫星结节灶和血管侵犯相关(P<0.05)。PBR蛋白阳性表达的患者总生存期和无复发生存期皆较阴性者短。Cox多因素分析结果显示,PBR蛋白表达水平是肝癌患者总生存期和无复发生存期的独立危险因素之一,且具有预后预测意义。【结论】PBR蛋白在肝细胞癌组中表达增加,且与肿瘤恶性程度和侵袭转移能力相关;PBR蛋白可作为对肝癌患者预后评估的独立分子标志物。

[ Objective ] To investigate the expression of peripheral benzodiazepine receptor （PBR） in human hepatocellular carcinoma （HCC） and its correlation with clinicopathologic characteristic and prognosis. [ Methods ] The expression of PBR protein was detected with immunohistochemical EnVision plus non-hiotin technique in 109 cases of human hepatocellular carcinomas. The correlation with characteristic and prognosis were statistically analyzed. [Results] The positive expression rate of PBR protein in human hepatocellular carcinomas was 62.4% （68/109）. The expression of PBR protein was positively related to tumor size, tumor differentiation, tumor capsular, satellite nodule and vascular invasion. The expression of PBR protein was correlation with poor overall survival （OS） and recurrence-free survival （RFS）. Furthermore, the expression of PBR protein was identified as an independent prognostic marker for OS and RFS though Cox multivariate analysis. [ Conclusion ] The expression of PBR protein was positive in most human HCC, and it was associated with tumor differentiation, invasion and metastasis. Furthermore, the expression of PBR protein was an independent prognostic marker for HCC.