丁苯酞治疗放射性脑病疗效观察

Therapeutic Effect of Butylphthalide on Patients with Radiation Encephalopathy

【目的】探讨丁苯酞对放射性脑病的治疗效果。【方法】选取我院头颈部肿瘤放射治疗后确诊放射性脑病患者80例,随机分为治疗组(丁苯酞+糖皮质激素常规治疗)与对照组(单纯糖皮质激素常规治疗)各40例。2组患者于治疗前后1月分别使用LENT/SOMA放射性损伤分级评估量表进行疗效评定。【结果】治疗组在头痛症状(总有效率76.74%)、神经功能障碍(总有效率80%)、认知功能(总有效率79.41%)及头颅核磁共振成像检查病灶变化(总有效率76.47%)4项指标评定疗效优于对照组,差别有统计学意义(P<0.05),2组在人格改变的疗效差别无统计学意义(P>0.05)。【结论】联合丁苯酞对于放射性脑病有较好的疗效。

[Objective] To evaluate the therapeutic effects of butylphthalide on radiation encephalopathy （REP）. [ Methods] Eighty patients with REP after radiotherapy were divided into the experimental group （conventional therapy combined with butylphthalide） and the control group （conventional therapy only） randomly. The clinical therapeutic effects were observed and evaluated by LENT/SOMA scores before and after treatment in these two groups, respectively. [ Results ] The therapeutic effects of headache （total efficiency 79.41%）, neurologic deficit （total efficiency 80%）, cognitive functions （total efficiency 79.41%） and MRI results （total efficiency 76.47%） were better in the experimental group than those in the control group （P 〈 0.05）. Nevertheless, there was no significant differences in mood and personality changes between these two groups. [Conclusions] Butylphthalide has an obvious therapeutic effect on REP.