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表观遗传调控与骨质疏松症的研究进展 被引量：8

Progress of epigenetic regulation in osteoporosis
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摘要 表观遗传指所有不通过DNA序列改变就能影响基因表达的、可遗传的调控方式,包括DNA甲基化、组蛋白修饰、染色质重塑和微小RNA(miRNA)等。骨质疏松的发生与环境和遗传因素的相互作用密不可分,其中涉及多种表观遗传调控机制。 Epigenetics is involved in heritable modifications such as DNA methylation, histone modification, chro matin remodeling, as well as miRNA, without changes in DNA sequence. It has been shown that occurence of oste oporosis is closely related to the interactions between the genome and enviroment, in which epigenetic regulation plays an important role.
作者 郑洁 郭海英 潘思京 张鹏飞
机构地区 南京中医药大学第二临床医学院 陕西中医学院针灸推拿系
出处 《基础医学与临床》 CSCD 北大核心 2014年第3期406-409,共4页 Basic and Clinical Medicine
关键词 表观遗传 骨质疏松症 DNA甲基化 组蛋白修饰 微小RNA epigenetics osteoporosis DNA methylation histone modification miRNA
分类号 R580 [医药卫生—内分泌]
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参考文献28

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同被引文献92

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基础医学与临床
2014年 第3期

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