摘要
程序性坏死是一种具有可调控的信号传导通路的细胞坏死方式。多种刺激可导致程序性坏死的发生,复合体Ⅰ、复合体Ⅱ和RIP1-RIP3坏死体是通路中的信号分子,而Necstatin-1是程序性坏死的特异性阻断剂。程序性坏死可能是缺血再灌注损伤中细胞死亡的重要方式。
Necroptosis is a special cell necrosis that is capable of being regulated through particular molecular mechanism. Multiple stimuli could induce necroptosis, complex Ⅰ , complex Ⅱ and RIP1-RIP3 necrosome are critical participants in the necroptosis. Also, necrostatin-1 is a special and potent small-molecular inhibitor of ne roptosis. Necroptosis could be an important alternative for cell death in ischemia-reperfusion injury.
出处
《基础医学与临床》
CSCD
北大核心
2014年第3期414-417,共4页
Basic and Clinical Medicine
