近视人群中角膜生物力学特性的分布(英文)

Corneal biomechanical properties distribution in myopic population

目的:分析伊朗近视眼及散光人群中角膜生物力学参数的分布特征。方法:对接受激光矫正手术的近视眼及散光患者180眼进行前后节、显然验光等效球镜度、Orbscan II和Zywave全面的术前检查。用眼反应分析仪测量角膜滞后量,角膜阻力因子,模拟Goldmann眼压值及角膜补偿后眼压值。分析所有角膜生物力学的分布特性及其与显然验光等效球镜度、性别和年龄的相关性。数据采用SPSS 17软件进行统计学分析,以P<0.05为有显著性差异。结果:平均年龄为28.20±6.78岁。平均显然验光等效球镜为-4.21±1.19D。平均角膜滞后量,角膜阻力因子,模拟Goldmann眼压值和角膜补偿后眼压值分别为10.00±1.28mmHg,10.17±1.45mmHg,15.71±2.67mmHg和16.68±2.41mmHg。近视人群中,28.4%角膜滞后量约为10mmHg,71%从9mmHg增长到11mmHg。25.9%的近视人群的角膜阻力因子为10mmHg,48.7%为9mmHg增长到11mmHg。显然验光等效球镜与角膜滞后量(Rs=0.001,P=0.71)和显然验光等效球镜与角膜阻力因子(Rs=0.01,P=0.18)之间正相关性不明显。结论:研究显示了伊朗近视眼人群中角膜生物力学的分布特征(角膜滞后量,角膜阻力因子,模拟Goldmann眼压值及角膜补偿后眼压值),并证实了角膜生物力学特性参数和显然验光等效球镜,年龄及性别之间没有统计学相关性。

AIM： To evaluate distribution of corneal biomechanical measurements in normal myopia and myopic -astigmatism population. 〈br〉 METHODS：One hundred and eighty eyes with myopia and myopic-astigmatism candidated for laser refractive surgery were included in this study. Complete examination of anterior and posterior segments, manifest refraction spherical equivalent （ MRSE ） , Orbscan and Zywave were performed preoperatively.Ocular response analyzer （ ORA） was used to measure corneal hysteresis （ CH ） , corneal resistance factor （ CRF ） , Goldmann -correlated intraocular pressure （ IOPg ） and corneal compensated I OP （ IOPcc ） . Distribution of all cor neal biomecha nica l pro perties and correlation between these parameters and MRSE, age and sex were determined. Statistical analysis was performed using SPSS 17 software and a P-Value less than 0.05 was considered significant. 〈br〉 RESULTS： Mean age was 28.20 ±6.78 years.Mean MRSE was-4.21±1.19D.Mean CH, CRF, IOPg and IOPcc was 10.00 ±1.28mmHg, 10.17 ±1.45mmHg, 15.71 ± 2.67mmHg and 16.68 ±2.41mmHg respectively.28.4% of all myopic population had CH about 10mmHg, and 71%had CH, 9mmHg up to 11mmHg.CRF in 25.9%of myopic population was 10mmHg, and in 48.7%was 9mmHg up to 11mmHg. There was very poor positive correlation between MRSE＆amp;CH （ Rs=0.001, P=0.71） and MRSE＆amp;CRF （Rs=0.01, P=0.18）. 〈br〉 CONCLUSION：Our study demonstrated the distribution of corneal biomechanical properties （CH, CRF, IOPg, IOPcc） in normal myopia and myopic-astigmatism population in Iran, and confirmed that, there was no statistically significant correlation between CH, CRF and MRSE, age and sex but there was significant correlation between IOPg, IOPcc and formerly mentioned parameters.