雷珠单抗和PDT治疗湿性AMD的疗效比较

Comparison of lucentis and photodynamic therapy in the treatment of wet age-related macular degeneration

目的:比较雷珠单抗和光动力疗法(photodynamic therapy,PDT)治疗湿性年龄相关性黄斑变性(age-related macular degeneration,AMD)的临床疗效。方法:回顾性分析23例PDT治疗的湿性AMD患者和23例予雷珠单抗玻璃体腔内注射治疗的湿性AMD患者的资料,比较两组在治疗后1,3,6mo的视力、OCT及FFA变化情况。结果:两组患者术后1,3mo视力均得到明显提高,两组在统计学意义上无显著差异,雷珠单抗组有2例(9%)患者在治疗后6mo出现视力回降现象,PDT组患者在术后3mo及术后6mo视力变化稳定。结论:雷珠单抗和PDT治疗湿性AMD,均能有效控制湿性AMD患者病情发展并能改善患者视力,两种疗法疗效的比较在短期内无统计学意义,但是术后6mo,PDT的稳定性优于雷珠单抗。

AIM： To compare the clinical curative effect with lucentis and photodynamic therapy in the disease of wet age-related macular degeneration. METHODS： A retrospective study in 23 cases with photodynamic therapy （ PDT ） , and another 23 patients who were injected lucentis.We compared the results of best corrected visual acuity, OCT and FFA after 1mo, 3mo and 6mo. RESULTS： Both groups had a great significant improvement in best corrected acuity visual at 1mo and 3mo later.The comparison between the two groups had no statistical significance.But the best corrected visual acuity in 2 patients （ 9%） of lucentis group was lower at 6mo than at 1mo and 3mo. CONCLUSION：The study showed the two methods for treating wet age -related macular degeneration were effective in short time, but the stability at 6mo of PDT group was better than lucentis group.