软骨寡聚基质蛋白在病理性瘢痕中的表达与意义

Expression of cartilage oligomeric matrix protein in pathological scar and its significance

目的 研究软骨寡聚基质蛋白在病理性瘢痕中的表达,探讨其在病理性瘢痕发病机制中的作用.方法 应用免疫组化技术检测软骨寡聚基质蛋白在30例瘢痕疙瘩（A组）、30例增生性瘢痕（B组）及20例正常皮肤（C组）中的表达,并进行统计学分析.结果 软骨寡聚基质蛋白在A、B组中的表达与C组比较,其差异具有统计学意义（P ＜0.05）,但A、B组之间的差异无统计学意义（P ＞0.05）.结论 软骨寡聚基质蛋白可能是病理性瘢痕产生与发展的重要因素,在病理性瘢痕的形成机制中可能起重要的作用.

Objective To investigate the expression of cartilage oligomeric matrix protein in pathological scar and to explore its role in the pathogenesis of pathological scar. Methods Eighty patients were divided into three groups; 30 cases of keloid were in the group A, 30 cases of hypertrophic scar were in the group B and 20 cases of normal skin were in the group C. Immunohistochemiscal technique was performed to detect the carti- lage oligomeric matrix protein expression and statistics was used to analyze the data. Results The cartilage oligo- meric matrix protein expression was significant difference between group A ,B and that group C （ P〈 0.05 ）, but the expression was not statistically different between group A and B （ P 〉 O. 05）. Conclusion Cartilage oligo- meric matrix protein may play an important role in the formation of pathological scar.