肿瘤相关长非编码RNA的表达及调控机制的研究进展

Mechanism of transcriptional regulation of tumor-related long non-coding RNA

肿瘤相关性长非编码RNA的研究尚处于方兴未艾的阶段,其表达与肿瘤侵袭、转移及预后有着密切的关系,但是有关其转录调控的研究仍然比较少见。本文介绍了长非编码RNA的组织细胞表达、与肿瘤侵袭转移和患者预后的关系、转录调控和表观遗传学调控研究的现状,探讨了本研究领域将来的发展方向。

Nowadays,research on tumor-related long non-coding RNAs is still at its infancy.However, growing evidence shows that long non-coding RNAs are involved in the invasion,metastasis and prognosis of tumor, but there is limited knowledge about the transcriptional regulation of these molecules.Here,we described the expression pattern of long non-coding RNAs in tissues and cells and evaluated its relationship with tumor invasion, metastasis and prognosis of human cancers.Also,we summarized the status quo of studies on the transcriptional and epigenetic regulation of long non-coding RNAs in order to provide an insight for future development of this rapidly advancing field.