三叉神经痛患者脑三叉神经诱发电位的临床研究

Clinical application of the latency and interpeak latency of brain trigeminal evoked potential in patients

目的检测三叉神经痛患者的脑三叉神经诱发电位潜伏期及峰间潜伏期,并与本实验室脑三叉神经诱发电位正常参考数据相比较。方法采用多导诱发电位仪,无创伤的表面皮肤刺激,三导联同时记录,检测16例三叉神经痛患者脑三叉神经诱发电位,获得患者脑三叉神经诱发电位的潜伏期及峰间潜伏期值。结果三叉神经痛患者同体两侧(患侧、健侧)各波潜伏期及峰间潜伏期相比较,无显著性差异(P>0.05)。患者患侧T1潜伏期与本实验室正常参考值相比较,有显著性差异(P<0.05);患者患侧T2潜伏期、T2-T1峰间潜伏期及患者健侧T2潜伏期、T2-T1峰间潜伏期与本实验室正常参考值相比较,无显著性差异(P>0.05)。结论在三叉神经痛患者的脑三叉神经诱发电位研究中,短潜伏期波有明显变化,更具有参考价值,为进一步研究三叉神经痛患者的脑三叉神经诱发电位变化等提供了一定的依据。

Objective To detect the latency and interpeak latency of trigeminal evoked potentials of trigeminal neuralgia patients and to compare the result with normal reference data obtained from healthy people in our laboratory. Methods The skin surface was stimulated the latency and interpeak latency of brain trigeminal evoked potentials in 16 trigeminal neuralgia patients were recorded with multiplying channels of evoked potential instrument. Results The latency data of the affected side and the normal side in the patients＇ homobody showed no significant difference, so was the result of the interpeak latency （P〈0.05）. T2 wave latency on the affected side, T2-T1 interpeak latency on the affected side, T1 wave latency on the unaffected side, T2-T1 interpeak latency on the unaffected side, or T2 wave latency on the unaffected side did not differ significantly from their respective normal reference data （P〉0.05）. However, T1 wave latency on the patients＇ affected side differed significantly from the normal reference data （P〈0.05）. Oonclusion Short latency wave changes obviously in the research on trigeminal neuralgia patients. It provides us with more evidence for further research on trigeminal evoked potential changes in trigeminal neuralgia patients.