胍基琥珀酸促进小鼠学习和记忆的作用(英文)

Promoting effects of guanidinosuccinic acid on learning and memory in mice

采用水迷宫实验和一次性被动回避实验 (跳台法和避暗法 ) ,研究了胍基琥珀酸 ( 14,2 8和 56mg·kg- 1,ip)对小鼠学习和记忆的影响 .在水迷宫实验中 ,给小鼠ip胍基琥珀酸 56mg·kg- 1,每日 1次 ,连给 4d ,明显改善小鼠的记忆功能 .无论 1次或连续 4dip上述 3个剂量的胍基琥珀酸对正常小鼠一次性被动回避实验均无明显影响 ,但能明显对抗樟柳碱 ( 5mg·kg- 1,ip) ,亚硝酸钠 ( 12 5mg·kg- 1,sc)和 10 %乙醇 ( 10mL·kg- 1,po)所引起的记忆障碍 .胍基琥珀酸的上述作用近似谷氨酸 ( 30 0mg·kg- 1,ip) .结果表明 ,胍基琥珀酸类似谷氨酸和其他兴奋性氨基酸 。

The effects of guanidinosuccinic acid (GSA) at three doses (14, 28, 56 mg·kg -1 , ip) on learning and memory in mice were studied by using water maze test and one trial passive avoidance test (step down and step through test). In water maze test, administration of GSA at a dose of 56 mg·kg -1 for continuous 4 days (once a day, ip) could significantly improve memory of mice at the fourth day. In normal mice, GSA at all three tested doses by acute and subacute (once a day, 4 days) administration had no significant effects on step down and step through tests, but could remarkably antagonize the memory impairment induced by anisodine (5 mg·kg -1 , ip), sodium nitrite (125 mg·kg -1 , sc) and 10% alcohol (10 mL·kg -1 , po) in both tests. These results suggest that GSA, like glutamate and other excitatory acids, play a role in regulation of learning and memory.