系统性红斑狼疮疾病专属量表联合普适性量表在系统性红斑狼疮患者中的应用

The application of systemic lupus erythematosus-specific quality of life questionnaire in systemic lupus erythematosus

目的将疾病专属量表与普适性量表相结合应用于SLE患者生活质量的评估。方法采用SEE专属的生活质量量表（SLEQOL）及健康调查简表（SF-36）对SLE患者进行问卷调查，记录基本信息，检测补体等血浆生物学指标。采用方差分析、相关分析及多元线性回归模型等进行统计分析。结果SLEQOL躯体功能以及SF-36健康变化均与SLEDAI积分呈正相关（r值分别为：0．36，0．19；P〈0．05）；而SF-36中生理机能、生理职能、情感职能、躯体疼痛及精力5个维度均与SLEDAI积分呈负相关（r值分别为：-0．20，-0．19，-0．19，-0．19，-0．21；P〈0．05）。重度活动组与病情无活动组及轻、中度活动组比较，SLEQOL躯体功能维度积分明显升高（18±10和11±5，12±6，13±7；P〈0。05）；与病情轻度活动组比较，中、重度活动组SF-36健康变化积分明显降低（23±28，14±17和34±39，P〈0．05）；与病情无活动组相比，轻度与重度活动组SF-36情感职能方面积分明显降低（30±4l，34±39干¨44___44，P〈0．05）；病程和学历是影响SLEQOL评分的因素。结论SLE患者生活质量与疾病活动度有关，且病程及学历可能是影响患者生活质量的主要因素。

Objective To elucidate the relationship between quality of life （QOL） and disease activity of systemic lupus erythematosus （SLE）, as well as to reveal the factors impacting disease activity and the QOL of SLE utilizing the combination of SLE-specific quality of life questionnaire （SLEQOL） and the medical outcomes survey short form 36 （SF-36）. Methods SLEQOL and SF-36 health survey questionnaire were applied. Information on gender, disease duration, age, education level were collected. Serum complement （C3 and C4） level and erythrocyte sedimentation rate （ESR） were measured. Patients were divided into inactive, mild active, moderate active and severe active respectively according to SLE disease activity index （SLEDAI） . Pearson＇s product moment correlation coefficient was used to analyze the correlation between the activity of disease and the QOL. Multiple linear regression was employed to explore the factors which could impact on SLEQOL. Results The physical function of SLEQOL was positively correlated with SLEDAI （r=0.36; P〈0.05）. The association between reported health transition of SF-36 and SLEDA[ was positive （r=0.19; P〈0.05）. Physical functioning, role-physical, role-emotional, body pain and vitality were all negatively correlated with SLEDAI （r： -0.20, -0.19, -0.19, -0.19, -0.21 respectively; P〈0.05）. The scores of patients with severe disease activity were significantly increased in the physical functioning of SLEQOL than other three groups （18±10 vs 11±5, 12±6, 13±7; P〈0.05）. Scores on the Health transition of patients with moderate and severe disease activity were lower than those of whom with mild disease activity （23±28, 14±17 vs 34±39, P〈0.05）. Patients with mild or severe disease activity had lower score than those of patients in disease inactive （30±41, 34±39 vs 44±44, P〈0.05）. Multiple linear regression analyses showed that disease duration and education level might be the influencing factors of SLEQOL. Conclusion QOL of patients with SLE is related to the level of disease activity and is impacted by disease duration and education.