小鼠肾脏髓襻细段发育的超微结构

THE ULTRASTRUCTURE OF IN DEVELOPMENT OF NEPHRON THIN SEGMENT IN MOUSE KIDNEY

目的 :探讨小鼠肾脏髓襻细段发生发育及逐渐成熟过程。方法 :应用光镜半薄切片和电镜超薄切片观察小鼠肾脏髓襻细段发育过程中的超微结构变化。结果和结论 :细段出现于胚胎后期 ,生后逐渐发育完善。上皮由立方细胞逐渐发育成扁平细胞过程中 ,细胞凋亡起着很大作用。细胞凋亡高峰时间发生在生后七天左右。超微结构观察发现生后细段完善主要位于长襻肾单位的细段。结论 :细段在胚胎晚期出现 ,生后发育。在这一过程中 ,特别是在细胞构筑过程中细胞凋亡起着重要作用。

Objective: To investigate the regular pattern of development of nephron thin segment in mice. Methods: Semithin sections and ultrathin sections were observed from embryonic kidney to postnatal kidney in mice. Results: Nephron thin segments were observed in the late stage of embryonic kidney and developed after birth. Cuboidal epithelium of thin segment were revealed in the late stage of embryonic kidney and apoptosis occured after birth, especially in the seventh day after birth. The thin segment with long loop were mainly developed into mature thin segment after birth. Conculstion: The epithelial cell of thin segment with long loop develops into mature thin segment mainly after birth. During the period of maturalion apoptosis plays an important role.