CⅡTA研究进展

Diagnostic Testing for Acute Coronary Artery Syndrome

CⅡTA(MHCclassⅡtransactivator)是近年新发现的转录活化因子 ,对MHCⅡ类分子的表达起严格且专一的调控作用。CⅡTA通过其细胞和组织专一性的启动子表达不同的转录本 ,并以此调节MHCⅡ类分子在不同组织及时段的特异性表达。CⅡTA蛋白与基础转录复合物及多种MHCⅡ类基因转录因子之间存在相互作用 ,并与之形成复合物以实现转录活化功能。对CⅡTA基因结构和功能的研究将极大地促进其在免疫调节和疾病治疗研究中的应用。

Acute coronary artery syndrome is a more and more serious public health problem with which every countries must be confronted. The time-dependent high lethaiity and the curability make the early diagnosis and risk stratification of acute coronary artery becoming very importam. In this article, we review the advances in early diagnostic testing of acute coronary artery syndrome.